Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. Here we report the discovery of a potent and selective DDR1 inhibitor, DDR1-IN-1, and present the 2.2 Å...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Kim, H, Tan, L, Weisberg, E, Liu, F, Canning, P, Choi, H, Ezell, SA, Wu, H, Zhao, Z, Wang, J, Mandinova, A, Griffin, J, Bullock, A, Liu, Q, Lee, S, Gray, N
التنسيق:	Journal article
اللغة:	English
منشور في:	2013

مواد مشابهة

Correction to Discovery of a Potent and Selective DDR1 Receptor Tyrosine Kinase Inhibitor.
حسب: Kim, H, وآخرون
منشور في: (2014)

Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors
حسب: Canning, P, وآخرون
منشور في: (2014)

Structural mechanisms determining inhibition of the collagen receptor DDR1 by selective and multi-targeted type II kinase inhibitors.
حسب: Canning, P, وآخرون
منشور في: (2014)

Tyrosine Kinase Inhibitors Display Potent Activity against Cryptosporidium parvum
حسب: Maria G. Nava, وآخرون
منشور في: (2023-02-01)

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.
حسب: López-Ramos, M, وآخرون
منشور في: (2010)

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights.
حسب: López-Ramos, M, وآخرون
منشور في: (2010)

Inhibitors of Discoidin Domain Receptor (DDR) Kinases for Cancer and Inflammation
حسب: William A. Denny, وآخرون
منشور في: (2021-11-01)

Editorial: Discovery of EGFR tyrosine kinase inhibitors for cancer treatment
حسب: Panupong Mahalapbutr, وآخرون
منشور في: (2024-02-01)

Discovery of Novel Naphthoquinone–Chalcone Hybrids as Potent FGFR1 Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Molecular Modeling
حسب: Ronnakorn Leechaisit, وآخرون
منشور في: (2023-08-01)

Masitinib (AB1010), a potent and selective tyrosine kinase inhibitor targeting KIT.
حسب: Patrice Dubreuil, وآخرون
منشور في: (2009-09-01)

Characterization of acquired receptor tyrosine–kinase fusions as mechanisms of resistance to EGFR tyrosine–kinase inhibitors
حسب: Xu H, وآخرون
منشور في: (2019-07-01)

Discovery of oncogenic ROS1 missense mutations with sensitivity to tyrosine kinase inhibitors
حسب: Sudarshan R Iyer, وآخرون
منشور في: (2023-10-01)

Recent Advances in Discovery of New Tyrosine Kinase Inhibitors Using Computational Methods
حسب: Vesna Rastija
منشور في: (2019-08-01)

Bioactive Phytoconstituents as Potent Inhibitors of Tyrosine-Protein Kinase Yes (YES1): Implications in Anticancer Therapeutics
حسب: Chunmin Yang, وآخرون
منشور في: (2022-05-01)

Small-molecule inhibitors of the c-Fes protein-tyrosine kinase.
حسب: Hellwig, S, وآخرون
منشور في: (2012)

New potent dual inhibitors of CK2 and Pim kinases: discovery and structural insights (September, pg 3175, 2010)
حسب: Lopez-Ramos, M, وآخرون
منشور في: (2011)

Kindlin-3 inactivation mediates melanoma agressiveness through crosstalk with the collagen-activated tyrosine kinase receptor DDR1
حسب: C. Reger de Moura, وآخرون
منشور في: (2024-01-01)

Selective Akt inhibitors synergize with tyrosine kinase inhibitors and effectively override stroma-associated cytoprotection of mutant FLT3-positive AML cells.
حسب: Ellen Weisberg, وآخرون
منشور في: (2013-01-01)

First‐in‐human study of deucravacitinib: A selective, potent, allosteric small‐molecule inhibitor of tyrosine kinase 2
حسب: Ian M. Catlett, وآخرون
منشور في: (2023-01-01)

TYROSINE KINASE INHIBITORS AND INTERFERON
حسب: Maria Dimou, وآخرون
منشور في: (2014-01-01)

TYROSINE KINASE INHIBITORS AND PREGNANCY
حسب: Elisabetta Abruzzese, وآخرون
منشور في: (2014-04-01)

Second-generation inhibitors of Bruton tyrosine kinase
حسب: Jingjing Wu, وآخرون
منشور في: (2016-09-01)

Discovery of novel dual inhibitors of receptor tyrosine kinases EGFR and IGF-1R
حسب: Cornelius Hempel, وآخرون
منشور في: (2017-01-01)

Discovery of Novel N-Substituted Prolinamido Indazoles as Potent Rho Kinase Inhibitors and Vasorelaxation Agents
حسب: Yangyang Yao, وآخرون
منشور في: (2017-10-01)

Tyrosine Kinase Inhibitors in Pulmonary Vascular Disease
حسب: John J. Ryan, MD
منشور في: (2016-12-01)

Exploration of type II binding mode: A privileged approach for kinase inhibitor focused drug discovery?
حسب: Zhao, Z, وآخرون
منشور في: (2014)

The two facets of receptor tyrosine kinase in cardiovascular calcification—can tyrosine kinase inhibitors benefit cardiovascular system?
حسب: Ainun Nizar Masbuchin, وآخرون
منشور في: (2022-09-01)

Tyrosine kinase inhibitor Tofacitinib. Safety issues
حسب: G. V. Lukina, وآخرون
منشور في: (2015-12-01)

Transarterial Chemoembolization Combined with Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors versus Immune Checkpoint Inhibitors Plus Tyrosine Kinase Inhibitors for Advanced Hepatocellular Carcinoma
حسب: Huang JT, وآخرون
منشور في: (2022-11-01)

Dual inhibition of Fes and Flt3 tyrosine kinases potently inhibits Flt3-ITD+ AML cell growth.
حسب: Mark C Weir, وآخرون
منشور في: (2017-01-01)

miR-494 in Extracellular Vesicles as a Potent Biomarker of Chronic Myeloid Leukemia Treatment with Tyrosine Kinase Inhibitors
حسب: Tatsuki Shibuta, وآخرون
منشور في: (2022-06-01)

Vorolanib, a novel tyrosine receptor kinase receptor inhibitor with potent preclinical anti-angiogenic and anti-tumor activity
حسب: Chris Liang, وآخرون
منشور في: (2022-03-01)

Mechanism and treatment of diarrhea associated with tyrosine kinase inhibitors
حسب: Jiangnan Liu, وآخرون
منشور في: (2024-03-01)

Acquired Hypothyroidism in Patients with Metastatic Renal Cell Carcinoma Treated with Tyrosine Kinase Inhibitors
حسب: Wu J, وآخرون
منشور في: (2020-09-01)

Integrating machine learning and structure-based approaches for repurposing potent tyrosine protein kinase Src inhibitors to treat inflammatory disorders
حسب: Muhammad Waleed Iqbal, وآخرون
منشور في: (2025-01-01)

Inhaled tyrosine kinase inhibitors for pulmonary hypertension: a possible future treatment
حسب: Pitsiou G, وآخرون
منشور في: (2014-10-01)

509 Potent and selective inhibition Of AXL receptor tyrosine kinase for the treatment of cancer
حسب: Matthew Walters, وآخرون
منشور في: (2020-11-01)

Activation of transmembrane receptor tyrosine kinase DDR1-STAT3 cascade by extracellular matrix remodeling promotes liver metastatic colonization in uveal melanoma
حسب: Wei Dai, وآخرون
منشور في: (2021-05-01)

Tetrahydroisoquinoline-7-carboxamide derivatives as new selective discoidin domain receptor 1 (DDR1) inhibitors
حسب: Bullock, A, وآخرون
منشور في: (2017)

Receptor Tyrosine Kinases and Inhibitors in Lung Cancer
حسب: Evan Pisick, وآخرون
منشور في: (2004-01-01)