Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor.

The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion. Here we report the discovery of a potent and selective DDR1 inhibitor, DDR1-IN-1, and present the 2.2 Å...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Kim, H, Tan, L, Weisberg, E, Liu, F, Canning, P, Choi, H, Ezell, SA, Wu, H, Zhao, Z, Wang, J, Mandinova, A, Griffin, J, Bullock, A, Liu, Q, Lee, S, Gray, N
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2013