The evolving cardiac lymphatic vasculature in development, repair and regeneration
The lymphatic vasculature has an essential role in maintaining normal fluid balance in tissues and modulating the inflammatory response to injury or pathogens. Disruption of normal development or function of lymphatic vessels can have severe consequences. In the heart, reduced lymphatic function can...
| Principais autores: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Springer Nature
2021
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| Assuntos: |
| _version_ | 1826263674174570496 |
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| author | Klaourakis, K Vieira, JM Riley, PR |
| author_facet | Klaourakis, K Vieira, JM Riley, PR |
| author_sort | Klaourakis, K |
| collection | OXFORD |
| description | The lymphatic vasculature has an essential role in maintaining normal fluid balance in tissues and modulating the inflammatory response to injury or pathogens. Disruption of normal development or function of lymphatic vessels can have severe consequences. In the heart, reduced lymphatic function can lead to myocardial oedema and persistent inflammation. Macrophages, which are phagocytic cells of the innate immune system, contribute to cardiac development and to fibrotic repair and regeneration of cardiac tissue after myocardial infarction. In this Review, we discuss the cardiac lymphatic vasculature with a focus on developments over the past 5 years arising from the study of mammalian and zebrafish model organisms. In addition, we examine the interplay between the cardiac lymphatics and macrophages during fibrotic repair and regeneration after myocardial infarction. Finally, we discuss the therapeutic potential of targeting the cardiac lymphatic network to regulate immune cell content and alleviate inflammation in patients with ischaemic heart disease. |
| first_indexed | 2024-03-06T19:55:33Z |
| format | Journal article |
| id | oxford-uuid:25741b11-d878-45eb-ab52-e63b631aaae3 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:55:33Z |
| publishDate | 2021 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | oxford-uuid:25741b11-d878-45eb-ab52-e63b631aaae32022-03-26T11:55:44ZThe evolving cardiac lymphatic vasculature in development, repair and regenerationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:25741b11-d878-45eb-ab52-e63b631aaae3LymphangiogenesisCardiac regenerationEnglishSymplectic ElementsSpringer Nature2021Klaourakis, KVieira, JMRiley, PRThe lymphatic vasculature has an essential role in maintaining normal fluid balance in tissues and modulating the inflammatory response to injury or pathogens. Disruption of normal development or function of lymphatic vessels can have severe consequences. In the heart, reduced lymphatic function can lead to myocardial oedema and persistent inflammation. Macrophages, which are phagocytic cells of the innate immune system, contribute to cardiac development and to fibrotic repair and regeneration of cardiac tissue after myocardial infarction. In this Review, we discuss the cardiac lymphatic vasculature with a focus on developments over the past 5 years arising from the study of mammalian and zebrafish model organisms. In addition, we examine the interplay between the cardiac lymphatics and macrophages during fibrotic repair and regeneration after myocardial infarction. Finally, we discuss the therapeutic potential of targeting the cardiac lymphatic network to regulate immune cell content and alleviate inflammation in patients with ischaemic heart disease. |
| spellingShingle | Lymphangiogenesis Cardiac regeneration Klaourakis, K Vieira, JM Riley, PR The evolving cardiac lymphatic vasculature in development, repair and regeneration |
| title | The evolving cardiac lymphatic vasculature in development, repair and regeneration |
| title_full | The evolving cardiac lymphatic vasculature in development, repair and regeneration |
| title_fullStr | The evolving cardiac lymphatic vasculature in development, repair and regeneration |
| title_full_unstemmed | The evolving cardiac lymphatic vasculature in development, repair and regeneration |
| title_short | The evolving cardiac lymphatic vasculature in development, repair and regeneration |
| title_sort | evolving cardiac lymphatic vasculature in development repair and regeneration |
| topic | Lymphangiogenesis Cardiac regeneration |
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