Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.
Osteosarcoma is a malignant bone tumor characterized by hypervascularity. Neuropilins (NRPs), which is expressed by human tumor cells, is known to be a potent receptor for vascular endothelial growth factor (VEGF). We examined NRPs mRNA expression in 30 osteosarcomas. The osteosarcomas with NRP2 exp...
| Autores principales: | , , , , , , , , |
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| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
2000
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| _version_ | 1826263676711075840 |
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| author | Handa, A Tokunaga, T Tsuchida, T Lee, Y Kijima, H Yamazaki, H Ueyama, Y Fukuda, H Nakamura, M |
| author_facet | Handa, A Tokunaga, T Tsuchida, T Lee, Y Kijima, H Yamazaki, H Ueyama, Y Fukuda, H Nakamura, M |
| author_sort | Handa, A |
| collection | OXFORD |
| description | Osteosarcoma is a malignant bone tumor characterized by hypervascularity. Neuropilins (NRPs), which is expressed by human tumor cells, is known to be a potent receptor for vascular endothelial growth factor (VEGF). We examined NRPs mRNA expression in 30 osteosarcomas. The osteosarcomas with NRP2 expression (n=24) showed a significantly increased vascularity (P<0.0014, Mann-Whitney U test). Osteosarcomas with NRP2 showed significantly poorer prognosis than those without NRP2 (P=0.016, Wilcoxon's test). These results suggest that NRP acts as a VEGF-amplifier in a paracrine or autocrine manner in the osteosarcoma. NRP2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression. |
| first_indexed | 2024-03-06T19:55:36Z |
| format | Journal article |
| id | oxford-uuid:25786e90-8c14-4ee1-85d7-aac1d0fdae31 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:55:36Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:25786e90-8c14-4ee1-85d7-aac1d0fdae312022-03-26T11:55:44ZNeuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:25786e90-8c14-4ee1-85d7-aac1d0fdae31EnglishSymplectic Elements at Oxford2000Handa, ATokunaga, TTsuchida, TLee, YKijima, HYamazaki, HUeyama, YFukuda, HNakamura, MOsteosarcoma is a malignant bone tumor characterized by hypervascularity. Neuropilins (NRPs), which is expressed by human tumor cells, is known to be a potent receptor for vascular endothelial growth factor (VEGF). We examined NRPs mRNA expression in 30 osteosarcomas. The osteosarcomas with NRP2 expression (n=24) showed a significantly increased vascularity (P<0.0014, Mann-Whitney U test). Osteosarcomas with NRP2 showed significantly poorer prognosis than those without NRP2 (P=0.016, Wilcoxon's test). These results suggest that NRP acts as a VEGF-amplifier in a paracrine or autocrine manner in the osteosarcoma. NRP2 expression cooperatively promotes angiogenesis and growth in osteosarcomas with VEGF expression. |
| spellingShingle | Handa, A Tokunaga, T Tsuchida, T Lee, Y Kijima, H Yamazaki, H Ueyama, Y Fukuda, H Nakamura, M Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. |
| title | Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. |
| title_full | Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. |
| title_fullStr | Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. |
| title_full_unstemmed | Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. |
| title_short | Neuropilin-2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma. |
| title_sort | neuropilin 2 expression affects the increased vascularization and is a prognostic factor in osteosarcoma |
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