Studies on the biomimetic synthesis of the manzamine alkaloids

The biomimetic synthesis of the manzamine-related alkaloid keramaphidin B is described. The key intramolecular Diels-Alder reaction proposed in the Baldwin and Whitehead hypothesis is demonstrated. An investigation of the modified biomimetic hypothesis proposed by Marazano et al. is also reported. F...

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Detalles Bibliográficos
Main Authors: Baldwin, J, Claridge, T, Culshaw, A, Heupel, F, Lee, V, Spring, DR, Whitehead, R
Formato: Journal article
Idioma:English
Publicado: 1999
Descripción
Summary:The biomimetic synthesis of the manzamine-related alkaloid keramaphidin B is described. The key intramolecular Diels-Alder reaction proposed in the Baldwin and Whitehead hypothesis is demonstrated. An investigation of the modified biomimetic hypothesis proposed by Marazano et al. is also reported. Finally, an alternative synthesis of keramaphidin B by Grubbs methathesis is presented.