Studies on the biomimetic synthesis of the manzamine alkaloids

The biomimetic synthesis of the manzamine-related alkaloid keramaphidin B is described. The key intramolecular Diels-Alder reaction proposed in the Baldwin and Whitehead hypothesis is demonstrated. An investigation of the modified biomimetic hypothesis proposed by Marazano et al. is also reported. F...

Полное описание

Библиографические подробности
Главные авторы: Baldwin, J, Claridge, T, Culshaw, A, Heupel, F, Lee, V, Spring, DR, Whitehead, R
Формат: Journal article
Язык:English
Опубликовано: 1999
Описание
Итог:The biomimetic synthesis of the manzamine-related alkaloid keramaphidin B is described. The key intramolecular Diels-Alder reaction proposed in the Baldwin and Whitehead hypothesis is demonstrated. An investigation of the modified biomimetic hypothesis proposed by Marazano et al. is also reported. Finally, an alternative synthesis of keramaphidin B by Grubbs methathesis is presented.