Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria.
Therapeutic responses to clindamycin in combination with quinine were assessed in adult Thai patients with uncomplicated multidrug-resistant Plasmodium falciparum malaria. In total 204 patients were randomized to receive a 7-day oral treatment regimen of quinine (Q(7)) either alone (n = 68), in comb...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1826263694752874496 |
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| author | Pukrittayakamee, S Chantra, A Vanijanonta, S Clemens, R Looareesuwan, S White, N |
| author_facet | Pukrittayakamee, S Chantra, A Vanijanonta, S Clemens, R Looareesuwan, S White, N |
| author_sort | Pukrittayakamee, S |
| collection | OXFORD |
| description | Therapeutic responses to clindamycin in combination with quinine were assessed in adult Thai patients with uncomplicated multidrug-resistant Plasmodium falciparum malaria. In total 204 patients were randomized to receive a 7-day oral treatment regimen of quinine (Q(7)) either alone (n = 68), in combination with clindamycin (Q(7)C(7); n = 68), or in combination with tetracycline (Q(7)T(7); n = 68). All patients had uncomplicated recoveries with no serious adverse effects. Fever clearance times for both of the two combination regimens (median of 47 h and range of 8 to 120 h for Q(7)C(7) and median of 36 h and range of 8 to 117 h for Q(7)T(7)) were significantly shorter than that for the Q(7)-only regimen (median, 56; range, 4 to 152 h) (P = 0.002). Parasite clearance times (overall mean +/- standard deviation, 78 +/- 23 h) were not significantly different between the three treatment groups (P = 0. 98). The cure rates assessed at 28 days of follow-up were 100% for Q(7)C(7) and 98% for Q(7)T(7), whereas the cure rate was 87% for the Q(7)-only regimen (P < or = 0.04). Clindamycin in combination with quinine is a safe and effective treatment for multidrug-resistant P. falciparum malaria. This combination may be of particular value in children and pregnant women, in whom tetracyclines are contraindicated. |
| first_indexed | 2024-03-06T19:55:53Z |
| format | Journal article |
| id | oxford-uuid:2592f427-7925-43cf-aaf7-6f05e09f8b3c |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:55:53Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:2592f427-7925-43cf-aaf7-6f05e09f8b3c2022-03-26T11:56:20ZTherapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2592f427-7925-43cf-aaf7-6f05e09f8b3cEnglishSymplectic Elements at Oxford2000Pukrittayakamee, SChantra, AVanijanonta, SClemens, RLooareesuwan, SWhite, NTherapeutic responses to clindamycin in combination with quinine were assessed in adult Thai patients with uncomplicated multidrug-resistant Plasmodium falciparum malaria. In total 204 patients were randomized to receive a 7-day oral treatment regimen of quinine (Q(7)) either alone (n = 68), in combination with clindamycin (Q(7)C(7); n = 68), or in combination with tetracycline (Q(7)T(7); n = 68). All patients had uncomplicated recoveries with no serious adverse effects. Fever clearance times for both of the two combination regimens (median of 47 h and range of 8 to 120 h for Q(7)C(7) and median of 36 h and range of 8 to 117 h for Q(7)T(7)) were significantly shorter than that for the Q(7)-only regimen (median, 56; range, 4 to 152 h) (P = 0.002). Parasite clearance times (overall mean +/- standard deviation, 78 +/- 23 h) were not significantly different between the three treatment groups (P = 0. 98). The cure rates assessed at 28 days of follow-up were 100% for Q(7)C(7) and 98% for Q(7)T(7), whereas the cure rate was 87% for the Q(7)-only regimen (P < or = 0.04). Clindamycin in combination with quinine is a safe and effective treatment for multidrug-resistant P. falciparum malaria. This combination may be of particular value in children and pregnant women, in whom tetracyclines are contraindicated. |
| spellingShingle | Pukrittayakamee, S Chantra, A Vanijanonta, S Clemens, R Looareesuwan, S White, N Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria. |
| title | Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria. |
| title_full | Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria. |
| title_fullStr | Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria. |
| title_full_unstemmed | Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria. |
| title_short | Therapeutic responses to quinine and clindamycin in multidrug-resistant falciparum malaria. |
| title_sort | therapeutic responses to quinine and clindamycin in multidrug resistant falciparum malaria |
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