The current status of enteric fever diagnostics and implications for disease control
Enteric (typhoid) fever remains a problem in low- and middle-income countries that lack the infrastructure to maintain sanitation and where inadequate diagnostic methods have restricted our ability to identify and control the disease more effectively. As we move into a period of potential disease el...
| Autores principales: | , , , , |
|---|---|
| Formato: | Journal article |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2020
|
| _version_ | 1826263703324983296 |
|---|---|
| author | Baker, S Blohmke, CJ Maes, M Johnston, PI Darton, TC |
| author_facet | Baker, S Blohmke, CJ Maes, M Johnston, PI Darton, TC |
| author_sort | Baker, S |
| collection | OXFORD |
| description | Enteric (typhoid) fever remains a problem in low- and middle-income countries that lack the infrastructure to maintain sanitation and where inadequate diagnostic methods have restricted our ability to identify and control the disease more effectively. As we move into a period of potential disease elimination through the introduction of typhoid conjugate vaccine (TCV), we again need to reconsider the role of typhoid diagnostics in how they can aid in facilitating disease control. Recent technological advances, including serology, transcriptomics, and metabolomics, have provided new insights into how we can detect signatures of invasive Salmonella organisms interacting with the host during infection. Many of these new techniques exhibit potential that could be further explored with the aim of creating a new enteric fever diagnostic to work in conjunction with TCV. We need a sustained effort within the enteric fever field to accelerate, validate, and ultimately introduce 1 (or more) of these methods to facilitate the disease control initiative. The window of opportunity is still open, but we need to recognize the need for communication with other research areas and commercial organizations to assist in the progression of these diagnostic approaches. The elimination of enteric fever is now becoming a real possibility, but new diagnostics need to be part of the equation and factored into future calculations for disease control. |
| first_indexed | 2024-03-06T19:56:02Z |
| format | Journal article |
| id | oxford-uuid:25a0ea51-5cf2-41d1-a2d5-4d5b332cf791 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:56:02Z |
| publishDate | 2020 |
| publisher | Oxford University Press |
| record_format | dspace |
| spelling | oxford-uuid:25a0ea51-5cf2-41d1-a2d5-4d5b332cf7912022-03-26T11:56:37ZThe current status of enteric fever diagnostics and implications for disease controlJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:25a0ea51-5cf2-41d1-a2d5-4d5b332cf791EnglishSymplectic ElementsOxford University Press2020Baker, SBlohmke, CJMaes, MJohnston, PIDarton, TCEnteric (typhoid) fever remains a problem in low- and middle-income countries that lack the infrastructure to maintain sanitation and where inadequate diagnostic methods have restricted our ability to identify and control the disease more effectively. As we move into a period of potential disease elimination through the introduction of typhoid conjugate vaccine (TCV), we again need to reconsider the role of typhoid diagnostics in how they can aid in facilitating disease control. Recent technological advances, including serology, transcriptomics, and metabolomics, have provided new insights into how we can detect signatures of invasive Salmonella organisms interacting with the host during infection. Many of these new techniques exhibit potential that could be further explored with the aim of creating a new enteric fever diagnostic to work in conjunction with TCV. We need a sustained effort within the enteric fever field to accelerate, validate, and ultimately introduce 1 (or more) of these methods to facilitate the disease control initiative. The window of opportunity is still open, but we need to recognize the need for communication with other research areas and commercial organizations to assist in the progression of these diagnostic approaches. The elimination of enteric fever is now becoming a real possibility, but new diagnostics need to be part of the equation and factored into future calculations for disease control. |
| spellingShingle | Baker, S Blohmke, CJ Maes, M Johnston, PI Darton, TC The current status of enteric fever diagnostics and implications for disease control |
| title | The current status of enteric fever diagnostics and implications for disease control |
| title_full | The current status of enteric fever diagnostics and implications for disease control |
| title_fullStr | The current status of enteric fever diagnostics and implications for disease control |
| title_full_unstemmed | The current status of enteric fever diagnostics and implications for disease control |
| title_short | The current status of enteric fever diagnostics and implications for disease control |
| title_sort | current status of enteric fever diagnostics and implications for disease control |
| work_keys_str_mv | AT bakers thecurrentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT blohmkecj thecurrentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT maesm thecurrentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT johnstonpi thecurrentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT dartontc thecurrentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT bakers currentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT blohmkecj currentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT maesm currentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT johnstonpi currentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol AT dartontc currentstatusofentericfeverdiagnosticsandimplicationsfordiseasecontrol |