Development of chemical probes for the bromodomains of BRD7 and BRD9

The bromodomain family of proteins are 'readers' of acetylated lysines of histones, a key mark in the epigenetic code of gene regulation. Without high quality chemical probes with which to study these proteins, their biological function, and potential use in therapeutics, remains unknown....

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Hlavní autoři: Clark, P, Dixon, D, Brennan, P
Médium: Journal article
Jazyk:English
Vydáno: Elsevier 2016