Viral hepatitis and liver cancer
Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause for HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million...
| Main Authors: | , , |
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| 格式: | Journal article |
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Royal Society
2017
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| _version_ | 1826263738786775040 |
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| author | Ringehan, M McKeating, J Protzer, U |
| author_facet | Ringehan, M McKeating, J Protzer, U |
| author_sort | Ringehan, M |
| collection | OXFORD |
| description | Hepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause for HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year. Owing to its high incidence and resistance to treatment, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases. The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease. Thus, understanding the role of hepatitis B and C viral infections in HCC development is essential for the future design of treatments and therapies for this cancer. In this review, we summarize the current knowledge on hepatitis B and C virus hepatocarcinogenesis and highlight direct and indirect risk factors. |
| first_indexed | 2024-03-06T19:56:36Z |
| format | Journal article |
| id | oxford-uuid:25d1f36b-bac6-4265-8f6c-421f756f01c8 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:56:36Z |
| publishDate | 2017 |
| publisher | Royal Society |
| record_format | dspace |
| spelling | oxford-uuid:25d1f36b-bac6-4265-8f6c-421f756f01c82022-03-26T11:57:42ZViral hepatitis and liver cancerJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:25d1f36b-bac6-4265-8f6c-421f756f01c8Symplectic Elements at OxfordRoyal Society2017Ringehan, MMcKeating, JProtzer, UHepatitis B and C viruses are a global health problem causing acute and chronic infections that can lead to liver cirrhosis and hepatocellular carcinoma (HCC). These infections are the leading cause for HCC worldwide and are associated with significant mortality, accounting for more than 1.3 million deaths per year. Owing to its high incidence and resistance to treatment, liver cancer is the second leading cause of cancer-related death worldwide, with HCC representing approximately 90% of all primary liver cancer cases. The majority of viral-associated HCC cases develop in subjects with liver cirrhosis; however, hepatitis B virus infection can promote HCC development without prior end-stage liver disease. Thus, understanding the role of hepatitis B and C viral infections in HCC development is essential for the future design of treatments and therapies for this cancer. In this review, we summarize the current knowledge on hepatitis B and C virus hepatocarcinogenesis and highlight direct and indirect risk factors. |
| spellingShingle | Ringehan, M McKeating, J Protzer, U Viral hepatitis and liver cancer |
| title | Viral hepatitis and liver cancer |
| title_full | Viral hepatitis and liver cancer |
| title_fullStr | Viral hepatitis and liver cancer |
| title_full_unstemmed | Viral hepatitis and liver cancer |
| title_short | Viral hepatitis and liver cancer |
| title_sort | viral hepatitis and liver cancer |
| work_keys_str_mv | AT ringehanm viralhepatitisandlivercancer AT mckeatingj viralhepatitisandlivercancer AT protzeru viralhepatitisandlivercancer |