The structural basis of ZMPSTE24-dependent laminopathies.

The structural basis of ZMPSTE24-dependent laminopathies.

Show other versions (1)

Mutations in the nuclear membrane zinc metalloprotease ZMPSTE24 lead to diseases of lamin processing (laminopathies), such as the premature aging disease progeria and metabolic disorders. ZMPSTE24 processes prelamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at two s...

Fuld beskrivelse

Bibliografiske detaljer
Main Authors:	Quigley, A, Dong, Y, Pike, A, Dong, L, Shrestha, L, Berridge, G, Stansfeld, P, Sansom, MS, Edwards, A, Bountra, C, von Delft, F, Bullock, A, Burgess-Brown, N, Carpenter, E
Format:	Journal article
Sprog:	English
Udgivet:	2013

Lignende værker

The structural basis of ZMPSTE24-dependent laminopathies
af: Quigley, A, et al.
Udgivet: (2013)

Mass spectrometry captures off-target drug binding and provides mechanistic insights into the human metalloprotease ZMPSTE24
af: Mehmood, S, et al.
Udgivet: (2016)

Prelamin A and ZMPSTE24 in premature and physiological aging
af: Howard J. Worman, et al.
Udgivet: (2023-12-01)

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA
af: Moritz Messner, et al.
Udgivet: (2020-08-01)

Requirements for efficient proteolytic cleavage of prelamin A by ZMPSTE24.
af: Jemima Barrowman, et al.
Udgivet: (2012-01-01)

Structures of ABCB10, a human ATP-binding cassette transporter in apo- and nucleotide-bound states.
af: Shintre, C, et al.
Udgivet: (2013)

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
af: Spear, ED, et al.
Udgivet: (2018)

ZMPSTE24 missense mutations that cause progeroid diseases decrease prelamin A cleavage activity and/or protein stability
af: Eric D. Spear, et al.
Udgivet: (2018-07-01)

Deciphering Nuclear Mechanobiology in Laminopathy
af: Jungwon Hah, et al.
Udgivet: (2019-03-01)

运用二代测序技术产前诊断ZMPSTE24基因突变
af: 麦明琴, et al.
Udgivet: (2017-01-01)

The Senolytic Drug Fisetin Attenuates Bone Degeneration in the Zmpste24−/− Progeria Mouse Model
af: William S. Hambright, et al.
Udgivet: (2023-01-01)

Targeting CK2 eliminates senescent cells and prolongs lifespan in Zmpste24-deficient mice
af: Jie Zhang, et al.
Udgivet: (2024-05-01)

Inhibition of Arenavirus Entry and Replication by the Cell-Intrinsic Restriction Factor ZMPSTE24 Is Enhanced by IFITM Antiviral Activity
af: Robert J. Stott-Marshall, et al.
Udgivet: (2022-02-01)

Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24.
af: Kaitlin M Wood, et al.
Udgivet: (2020-01-01)

Clinical and genetic characteristics of hereditary laminopathies
af: E. L. Dadaly, et al.
Udgivet: (2017-02-01)

Clinical and diagnostic difficulties in management of patients with laminopathies
af: O. V. Melnik, et al.
Udgivet: (2019-11-01)

Accelerated aging in articular cartilage by ZMPSTE24 deficiency leads to osteoarthritis with impaired metabolic signaling and epigenetic regulation
af: Jinlong Suo, et al.
Udgivet: (2023-05-01)

A Heterozygous ZMPSTE24 Mutation Associated with Severe Metabolic Syndrome, Ectopic Fat Accumulation, and Dilated Cardiomyopathy
af: Damien Galant, et al.
Udgivet: (2016-04-01)

Deficiency in ZMPSTE24 and resulting farnesyl–prelamin A accumulation only modestly affect mouse adipose tissue stores[S]
af: Patrick J. Heizer, et al.
Udgivet: (2020-03-01)

Cellular and Animal Models of Striated Muscle Laminopathies
af: Hannah A. Nicolas, et al.
Udgivet: (2019-03-01)

AN ORPHAN PHENOTYPE OF CARDIOGENITAL LAMINOPATHY — MALOUF SYNDROME
af: T. G. Vaykhanskaya, et al.
Udgivet: (2016-11-01)

Restrictive Dermopathy Due to ZMPSTE24 Mutation: A Case Report with a Novel Finding of Corpus Callosum Agenesis
af: Minu Jose Chiramel, et al.
Udgivet: (2024-01-01)

Lamin A/C Mechanotransduction in Laminopathies
af: Francesca Donnaloja, et al.
Udgivet: (2020-05-01)

Nuclear damages and oxidative stress: new perspectives for laminopathies
af: G. Lattanzi, et al.
Udgivet: (2012-10-01)

Structural basis for ASPP2 recognition by the tumor suppressor p73
af: Canning, P, et al.
Udgivet: (2012)

Structural basis for ASPP2 recognition by the tumor suppressor p73.
af: Canning, P, et al.
Udgivet: (2012)

Cardiac involvement in laminopathies – short invited review
af: Gerardo Nigro, et al.
Udgivet: (2015-12-01)

Implications and Assessment of the Elastic Behavior of Lamins in Laminopathies
af: Subarna Dutta, et al.
Udgivet: (2016-10-01)

Inflammatory myopathy in the context of an unusual overlapping laminopathy
af: Cristina Guillín-Amarelle, et al.
Udgivet: (2018-05-01)

The empowerment of translational research: lessons from laminopathies
af: Benedetti Sara, et al.
Udgivet: (2012-06-01)

HIV protease inhibitors inhibit FACE1/ZMPSTE24: a mechanism for acquired lipodystrophy in patients on highly active antiretroviral therapy?
af: Goulbourne, C, et al.
Udgivet: (2010)

Simulations of the BM2 proton channel transmembrane domain from influenza virus B.
af: Rouse, S, et al.
Udgivet: (2009)

Embryonic Senescence and Laminopathies in a Progeroid Zebrafish Model
af: Koshimizu, Eriko, et al.
Udgivet: (2011)

Embryonic senescence and laminopathies in a progeroid zebrafish model.
af: Eriko Koshimizu, et al.
Udgivet: (2011-03-01)

Risk stratification in laminopathies and Emery Dreifuss muscular dystrophy
af: Abdallah Fayssoil
Udgivet: (2018-04-01)

Emery-Dreifuss muscular dystrophy: the most recognizable laminopathy
af: Agnieszka Madej-Pilarczyk, et al.
Udgivet: (2016-03-01)

Aberrant chromatin organization at the nexus of laminopathy disease pathways
af: Garrett T. Santini, et al.
Udgivet: (2022-12-01)

The farnesyl transferase inhibitor (FTI) lonafarnib improves nuclear morphology in ZMPSTE24-deficient fibroblasts from patients with the progeroid disorder MAD-B
af: Kamsi O. Odinammadu, et al.
Udgivet: (2023-12-01)

The Integral Membrane Protein ZMPSTE24 Protects Cells from SARS-CoV-2 Spike-Mediated Pseudovirus Infection and Syncytia Formation
af: Khurts Shilagardi, et al.
Udgivet: (2022-10-01)

Nuclear envelope proteins and chromatin arrangement: a pathogenic mechanism for laminopathies
af: NM Maraldi, et al.
Udgivet: (2009-06-01)