The structural basis of ZMPSTE24-dependent laminopathies.

The structural basis of ZMPSTE24-dependent laminopathies.

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Mutations in the nuclear membrane zinc metalloprotease ZMPSTE24 lead to diseases of lamin processing (laminopathies), such as the premature aging disease progeria and metabolic disorders. ZMPSTE24 processes prelamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at two s...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Quigley, A, Dong, Y, Pike, A, Dong, L, Shrestha, L, Berridge, G, Stansfeld, P, Sansom, MS, Edwards, A, Bountra, C, von Delft, F, Bullock, A, Burgess-Brown, N, Carpenter, E
Format: Journal article
Sprache:English
Veröffentlicht: 2013

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