The structural basis of ZMPSTE24-dependent laminopathies.

The structural basis of ZMPSTE24-dependent laminopathies.

Näytä muut versiot (1)

Mutations in the nuclear membrane zinc metalloprotease ZMPSTE24 lead to diseases of lamin processing (laminopathies), such as the premature aging disease progeria and metabolic disorders. ZMPSTE24 processes prelamin A, a component of the nuclear lamina intermediate filaments, by cleaving it at two s...

Bibliografiset tiedot
Päätekijät:	Quigley, A, Dong, Y, Pike, A, Dong, L, Shrestha, L, Berridge, G, Stansfeld, P, Sansom, MS, Edwards, A, Bountra, C, von Delft, F, Bullock, A, Burgess-Brown, N, Carpenter, E
Aineistotyyppi:	Journal article
Kieli:	English
Julkaistu:	2013

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