K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study.

K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study.

Molecular dynamics simulations of a bacterial potassium channel (KcsA) embedded in a phospholipid bilayer reveal significant differences in interactions of the selectivity filter with K(+) compared with Na(+) ions. K(+) ions and water molecules within the filter undergo concerted single-file motion...

Full beskrivning

Bibliografiska uppgifter
Huvudupphovsmän:	Shrivastava, I, Tieleman, D, Biggin, P, Sansom, MS
Materialtyp:	Journal article
Språk:	English
Publicerad:	2002

Liknande verk

Simulation approaches to ion channel structure-function relationships.
av: Tieleman, D, et al.
Publicerad: (2001)

Understanding pH-dependent selectivity of alamethicin K18 channels by computer simulation.
av: Tieleman, D, et al.
Publicerad: (2003)

The selectivity of K+ ion channels: testing the hypotheses.
av: Fowler, P, et al.
Publicerad: (2008)

Potassium and sodium ions in a potassium channel studied by molecular dynamics simulations.
av: Biggin, P, et al.
Publicerad: (2001)

Gating at the selectivity filter of ion channels that conduct Na+ and K+ ions.
av: Furini, S, et al.
Publicerad: (2011)

Water in ion channels and pores--simulation studies.
av: Sansom, MS, et al.
Publicerad: (2002)

Proline-induced hinges in transmembrane helices: possible roles in ion channel gating.
av: Tieleman, D, et al.
Publicerad: (2001)

Simulation approaches to ion channel gating
av: Biggin, P, et al.
Publicerad: (2002)

Structure and dynamics of K channel pore-lining helices: a comparative simulation study.
av: Shrivastava, I, et al.
Publicerad: (2000)

Filter flexibility in a mammalian K channel: models and simulations of Kir6.2 mutants.
av: Capener, C, et al.
Publicerad: (2003)

Simulations of ion channels--watching ions and water move.
av: Sansom, MS, et al.
Publicerad: (2000)

Ion channels: a first view of K⁺ channels in atomic glory
av: Sansom, M
Publicerad: (1998)

Simulations of ion permeation through a potassium channel: molecular dynamics of KcsA in a phospholipid bilayer.
av: Shrivastava, I, et al.
Publicerad: (2000)

Ion channels: frozen motion.
av: Sansom, MS, et al.
Publicerad: (2002)

Filter flexibility and distortion in a bacterial inward rectifier K+ channel: simulation studies of KirBac1.1.
av: Domene, C, et al.
Publicerad: (2004)

MicroED structure of the NaK ion channel reveals a Na+ partition process into the selectivity filter
av: Shian Liu, et al.
Publicerad: (2018-05-01)

Potassium channels: structures, models, simulations.
av: Sansom, MS, et al.
Publicerad: (2002)

Analysis and evaluation of channel models: simulations of alamethicin.
av: Tieleman, D, et al.
Publicerad: (2002)

K(+) and Na(+) conduction in selective and nonselective ion channels via molecular dynamics simulations.
av: Furini, S, et al.
Publicerad: (2013)

Channel gating and proline-containing helices - Simulation studies of Kv S6 and related systems
av: Sansom, M, et al.
Publicerad: (2001)

Molecular dynamics simulations of a K channel model: Sensitivity to changes in ions, waters, and membrane environment
av: Capener, C, et al.
Publicerad: (2002)

K+ channels - Homology models and and stimulations
av: Sansom, M, et al.
Publicerad: (2000)

Conformational plasticity of NaK2K and TREK2 potassium channel selectivity filters
av: Marcos Matamoros, et al.
Publicerad: (2023-01-01)

Molecular dynamics simulations of the Shaker voltage-gated K+ channel: Open vs closed structural model
av: Shrivastava, I, et al.
Publicerad: (2002)

Simulation studies of the interaction of antimicrobial peptides and lipid bilayers.
av: La Rocca, P, et al.
Publicerad: (1999)

Molecular dynamics simulations and KcsA channel gating.
av: Shrivastava, I, et al.
Publicerad: (2002)

Ion channel gating: insights via molecular simulations.
av: Beckstein, O, et al.
Publicerad: (2003)

Molecular dynamics simulations of a K+ channel blocker: Tc1 toxin from Tityus cambridgei.
av: Grottesi, A, et al.
Publicerad: (2003)

A binding-block ion selective mechanism revealed by a Na/K selective channel
av: Jie Yu, et al.
Publicerad: (2017-09-01)

Mechanism of activation at the selectivity filter of the KcsA K+ channel
av: Florian T Heer, et al.
Publicerad: (2017-10-01)

Molecular dynamics simulation approaches to K channels: conformational flexibility and physiological function.
av: Grottesi, A, et al.
Publicerad: (2005)

Water in transmembrane pores: Simulation studies.
av: Sansom, M, et al.
Publicerad: (2001)

A single NaK channel conformation is not enough for non-selective ion conduction
av: Chaowei Shi, et al.
Publicerad: (2018-02-01)

Selectivity and permeation of alkali metal ions in K +-channels
av: Furini, S, et al.
Publicerad: (2011)

Selectivity and permeation of alkali metal ions in K+-channels.
av: Furini, S, et al.
Publicerad: (2011)

Correction to: A binding-block ion selective mechanism revealed by a Na/K selective channel
av: Jie Yu, et al.
Publicerad: (2019-03-01)

Electrostatics studies and molecular dynamics simulations of a homology model of the Shaker K+ channel pore.
av: Ranatunga, K, et al.
Publicerad: (2001)

Exploring models of the influenza A M2 channel: MD simulations in a phospholipid bilayer.
av: Forrest, L, et al.
Publicerad: (2000)

Open-state models of a potassium channel.
av: Biggin, P, et al.
Publicerad: (2002)

Molecular dynamics simulations of antimicrobial peptides: From membrane binding to trans-membrane channels
av: Tieleman, D, et al.
Publicerad: (2001)