Human leukocyte antigen class II associations with systemic sclerosis in South Africans.
Human leukocyte antigen class II typing, using polymerase chain reaction-sequence-specific primers, was performed in 52 Black South Africans with systemic sclerosis (SSc) and 112 controls. Increased frequencies of DR2 in the overall SSc group (OR = 2.4), DRB1*0301 in the limited cutaneous SSc (lcSSc...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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2004
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| _version_ | 1826263768088182784 |
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| author | Tikly, M Rands, A McHugh, N Wordsworth, P Welsh, K |
| author_facet | Tikly, M Rands, A McHugh, N Wordsworth, P Welsh, K |
| author_sort | Tikly, M |
| collection | OXFORD |
| description | Human leukocyte antigen class II typing, using polymerase chain reaction-sequence-specific primers, was performed in 52 Black South Africans with systemic sclerosis (SSc) and 112 controls. Increased frequencies of DR2 in the overall SSc group (OR = 2.4), DRB1*0301 in the limited cutaneous SSc (lcSSc) subset (OR = 9.0), and DQB1*0301/4 in the diffuse cutaneous SSc (dcSSc) subset (OR = 9.0) were observed. Pulmonary fibrosis was associated with DRB1*11 and anti-topoisomerase I antibodies were associated with DPB1*1301 and DRB1*15. Patients with anti-fibrillarin antibodies (AFAs) had increased the frequencies of DRB1*1101 allele group (OR = 16) and DQB1*0603/14 (OR = 13.6). These findings provide new serological and immunogenetic data on a previously unreported population. The association of AFAs with class II alleles merits further investigation. |
| first_indexed | 2024-03-06T19:57:05Z |
| format | Journal article |
| id | oxford-uuid:25fcdf96-47d4-42dd-9aa7-72095242d178 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:57:05Z |
| publishDate | 2004 |
| record_format | dspace |
| spelling | oxford-uuid:25fcdf96-47d4-42dd-9aa7-72095242d1782022-03-26T11:58:29ZHuman leukocyte antigen class II associations with systemic sclerosis in South Africans.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:25fcdf96-47d4-42dd-9aa7-72095242d178EnglishSymplectic Elements at Oxford2004Tikly, MRands, AMcHugh, NWordsworth, PWelsh, KHuman leukocyte antigen class II typing, using polymerase chain reaction-sequence-specific primers, was performed in 52 Black South Africans with systemic sclerosis (SSc) and 112 controls. Increased frequencies of DR2 in the overall SSc group (OR = 2.4), DRB1*0301 in the limited cutaneous SSc (lcSSc) subset (OR = 9.0), and DQB1*0301/4 in the diffuse cutaneous SSc (dcSSc) subset (OR = 9.0) were observed. Pulmonary fibrosis was associated with DRB1*11 and anti-topoisomerase I antibodies were associated with DPB1*1301 and DRB1*15. Patients with anti-fibrillarin antibodies (AFAs) had increased the frequencies of DRB1*1101 allele group (OR = 16) and DQB1*0603/14 (OR = 13.6). These findings provide new serological and immunogenetic data on a previously unreported population. The association of AFAs with class II alleles merits further investigation. |
| spellingShingle | Tikly, M Rands, A McHugh, N Wordsworth, P Welsh, K Human leukocyte antigen class II associations with systemic sclerosis in South Africans. |
| title | Human leukocyte antigen class II associations with systemic sclerosis in South Africans. |
| title_full | Human leukocyte antigen class II associations with systemic sclerosis in South Africans. |
| title_fullStr | Human leukocyte antigen class II associations with systemic sclerosis in South Africans. |
| title_full_unstemmed | Human leukocyte antigen class II associations with systemic sclerosis in South Africans. |
| title_short | Human leukocyte antigen class II associations with systemic sclerosis in South Africans. |
| title_sort | human leukocyte antigen class ii associations with systemic sclerosis in south africans |
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