Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.

Novel function of the cyclin A binding site of E2F in regulating p53-induced apoptosis in response to DNA damage.

We demonstrate here that the E2F1 induced by DNA damage can bind to and promote the apoptotic function of p53 via the cyclin A binding site of E2F1. This function of E2F1 does not require its DP-1 binding, DNA binding, or transcriptional activity and is independent of mdm2. All the cyclin A binding...

Full description

Bibliographic Details
Main Authors:	Hsieh, J, Yap, D, O'Connor, D, Fogal, V, Fallis, L, Chan, F, Zhong, S, Lu, X
Format:	Journal article
Language:	English
Published:	2002

Similar Items

Cell cycle-dependent nuclear retention of p53 by E2F1 requires phosphorylation of p53 at Ser315.
by: Fogal, V, et al.
Published: (2005)

The biological response of MCF7 breast cancer cells to proteosome inhibition or gamma-radiation is unrelated to the level of p53 induction.
by: Fallis, L, et al.
Published: (1999)

p53 phosphorylation mutants retain transcription activity.
by: Fuchs, B, et al.
Published: (1995)

RB regulates the stability and the apoptotic function of p53 via MDM2.
by: Hsieh, J, et al.
Published: (1999)

Stress signals induce transcriptionally inactive E2F-1 independently of p53 and Rb.
by: O'Connor, D, et al.
Published: (2000)

Divergent evolution of human p53 binding sites: cell cycle versus apoptosis.
by: Monica M Horvath, et al.
Published: (2007-07-01)

E2F1 induced apoptosis requires DNA binding but not transcriptional activity and is inhibited by RB
by: Hsieh, J, et al.
Published: (1997)

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis
by: D'Angiolella, V, et al.
Published: (2012)

A cyclin without cyclin-dependent kinases: cyclin F controls genome stability through ubiquitin-mediated proteolysis.
by: D'Angiolella, V, et al.
Published: (2013)

Posttranslational modifications of p27kip1 determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo.
by: Zhang, W, et al.
Published: (2005)

A cyclin without cyclin-dependent kinases: Cyclin F controls genome stability through ubiquitin-mediated proteolysis
by: D'Angiolella, V, et al.
Published: (2013)

Pellino1 specifically binds to phospho-Thr18 of p53 and is recruited to sites of DNA damage
by: Dai, Liang, et al.
Published: (2021)

Ets-1 binds cooperatively to the palindromic Ets-binding sites in the p53 promoter.
by: Baillat, D, et al.
Published: (2009)

Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1.
by: O'Connor, D, et al.
Published: (1995)

Site-specific phosphorylation of the DNA damage response mediator rad9 by cyclin-dependent kinases regulates activation of checkpoint kinase 1.
by: Carla Manuela Abreu, et al.
Published: (2013-04-01)

mdm2: a bridge over the two tumour suppressors, p53 and Rb.
by: Yap, D, et al.
Published: (1999)

To die or not to die: how does p53 decide?
by: Slee, E, et al.
Published: (2004)

Deciphering the binding behavior of flavonoids to the cyclin dependent kinase 6/cyclin D complex.
by: Jingxiao Zhang, et al.
Published: (2018-01-01)

E2F1 proteolysis via SCF-cyclin F underlies synthetic lethality between cyclin F loss and Chk1 inhibition
by: Burdova, K, et al.
Published: (2019)

E2F and p53 induce apoptosis independently during Drosophila development but intersect in the context of DNA damage.
by: Nam-Sung Moon, et al.
Published: (2008-08-01)

ASPP proteins specifically stimulate the apoptotic function of p53.
by: Samuels-Lev, Y, et al.
Published: (2001)

DAXX-ATRX regulation of p53 chromatin binding and DNA damage response
by: Nitish Gulve, et al.
Published: (2022-08-01)

Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer
by: Yuan Yuan, et al.
Published: (2022-09-01)

Cyclin B2 impairs the p53 signaling in nasopharyngeal carcinoma
by: Qinsong Liu, et al.
Published: (2024-01-01)

Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation.
by: Yap, D, et al.
Published: (2000)

p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo
by: Oleg Timofeev, et al.
Published: (2013-05-01)

Blue Light Damage and p53: Unravelling the Role of p53 in Oxidative-Stress-Induced Retinal Apoptosis
by: Agnes Fietz, et al.
Published: (2023-12-01)

Proapoptotic p53-interacting protein 53BP2 is induced by UV irradiation but suppressed by p53
by: Lopez, C, et al.
Published: (2000)

PENGARUH METFORMIN TERHADAP PENEKANAN EKSPRESI CYCLIN D1, AKTIVASI p53 DAN INDUKSI APOPTOSIS PADA KULTUR SEL HELA
by: , RATIH DEWI YUDHANI, et al.
Published: (2014)

Degradation of p27(Kip) cdk inhibitor triggered by Kaposi's sarcoma virus cyclin-cdk6 complex.
by: Ellis, M, et al.
Published: (1999)

Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM–CHK2 Pathway
by: Yusuke Niwa, et al.
Published: (2022-02-01)

GFI1 is repressed by p53 and inhibits DNA damage-induced apoptosis.
by: Pei Du, et al.
Published: (2013-01-01)

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction.
by: Hsieh, J, et al.
Published: (1997)

Ser392 phosphorylation regulates the oncogenic function of mutant p53.
by: Yap, D, et al.
Published: (2004)

Impact of Alu repeats on the evolution of human p53 binding sites
by: Sirotin Michael V, et al.
Published: (2011-01-01)

Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions
by: Ji-Hyun Lim, et al.
Published: (2016-10-01)

Cluster Analysis of p53 Binding Site Sequences Reveals Subsets with Different Functions
by: Ji-Hyun Lim, et al.
Published: (2016-01-01)

Damaged-DNA Binding Protein-2 Drives Apoptosis Following DNA Damage
by: Raychaudhuri Pradip, et al.
Published: (2010-01-01)

ASPP1 and ASPP2 are new transcriptional targets of E2F.
by: Fogal, V, et al.
Published: (2005)

Retraction: Recombinant Human Adenovirus-p53 Injection Induced Apoptosis in Hepatocellular Carcinoma Cell Lines Mediated by p53-Fbxw7 Pathway, Which Controls c-Myc and Cyclin E.
by: PLOS ONE Editors
Published: (2020-01-01)