Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.
Bicyclic lactams derived from pyroglutamic acid provide a useful scaffold for synthesis of conformationally restricted analogues of lysine, ornithine and glutamine, as well as an Ala-Ala dipeptide analogue. Amino alcohol and carboxylic acid derivatives are accessible from a common intermediate. In t...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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2005
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| _version_ | 1797058957170180096 |
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| author | Bentz, E Goswami, R Moloney, M Westaway, S |
| author_facet | Bentz, E Goswami, R Moloney, M Westaway, S |
| author_sort | Bentz, E |
| collection | OXFORD |
| description | Bicyclic lactams derived from pyroglutamic acid provide a useful scaffold for synthesis of conformationally restricted analogues of lysine, ornithine and glutamine, as well as an Ala-Ala dipeptide analogue. Amino alcohol and carboxylic acid derivatives are accessible from a common intermediate. In this strategy, the bicyclic lactam system not only controls, but also facilitates the determination of the stereochemistry of the synthetic intermediates. |
| first_indexed | 2024-03-06T19:57:24Z |
| format | Journal article |
| id | oxford-uuid:2617d893-fbc8-454e-bd52-2206b64e1cf1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:57:24Z |
| publishDate | 2005 |
| record_format | dspace |
| spelling | oxford-uuid:2617d893-fbc8-454e-bd52-2206b64e1cf12022-03-26T11:59:02ZStereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2617d893-fbc8-454e-bd52-2206b64e1cf1EnglishSymplectic Elements at Oxford2005Bentz, EGoswami, RMoloney, MWestaway, SBicyclic lactams derived from pyroglutamic acid provide a useful scaffold for synthesis of conformationally restricted analogues of lysine, ornithine and glutamine, as well as an Ala-Ala dipeptide analogue. Amino alcohol and carboxylic acid derivatives are accessible from a common intermediate. In this strategy, the bicyclic lactam system not only controls, but also facilitates the determination of the stereochemistry of the synthetic intermediates. |
| spellingShingle | Bentz, E Goswami, R Moloney, M Westaway, S Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. |
| title | Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. |
| title_full | Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. |
| title_fullStr | Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. |
| title_full_unstemmed | Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. |
| title_short | Stereoselective synthesis of conformationally constrained omega-amino acid analogues from pyroglutamic acid. |
| title_sort | stereoselective synthesis of conformationally constrained omega amino acid analogues from pyroglutamic acid |
| work_keys_str_mv | AT bentze stereoselectivesynthesisofconformationallyconstrainedomegaaminoacidanaloguesfrompyroglutamicacid AT goswamir stereoselectivesynthesisofconformationallyconstrainedomegaaminoacidanaloguesfrompyroglutamicacid AT moloneym stereoselectivesynthesisofconformationallyconstrainedomegaaminoacidanaloguesfrompyroglutamicacid AT westaways stereoselectivesynthesisofconformationallyconstrainedomegaaminoacidanaloguesfrompyroglutamicacid |