Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients
<p>The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T 2 relaxation time changes in ischaemic brain such that T 2 in ADC lesions may be informative of the extent of t...
| Автори: | , , , , , , , , , , , , |
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| Формат: | Journal article |
| Мова: | English |
| Опубліковано: |
IOP Publishing
2019
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| _version_ | 1826263798946725888 |
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| author | Damion, R Knight, M McGarry, B Bosnell, R Jezzard, P Harston, G Carone, D Kennedy, J El-Tawil, S Elliot, J Muir, K Clatworthy, P Kauppinen, R |
| author_facet | Damion, R Knight, M McGarry, B Bosnell, R Jezzard, P Harston, G Carone, D Kennedy, J El-Tawil, S Elliot, J Muir, K Clatworthy, P Kauppinen, R |
| author_sort | Damion, R |
| collection | OXFORD |
| description | <p>The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T 2 relaxation time changes in ischaemic brain such that T 2 in ADC lesions may be informative of the extent of tissue damage, potentially aiding in stratification for treatment. We have developed a novel user-unbiased method of determining the changes in T 2 in ADC lesions as a function of clinical symptom duration based on voxel-wise referencing to a contralateral brain volume. The spherical reference method calculates the most probable pre-ischaemic T 2 on a voxel-wise basis, making use of features of the contralateral hemisphere presumed to be largely unaffected. We studied whether T 2 changes in the two main cerebral tissue types, i.e. in grey matter (GM) and white matter (WM), would differ in stroke.</p><br/>
<p>Thirty-eight acute stroke patients were accrued within 9 h of symptom onset and scanned at 3 T for 3D T 1-weighted, multi b-value diffusion and multi-echo spin echo MRI for tissue type segmentation, quantitative ADC and absolute T 2 images, respectively. T 2 changes measured by the spherical reference method were 1.94 ± 0.61, 1.50 ± 0.52 and 1.40 ± 0.54 ms h−1 in the whole, GM, and WM lesions, respectively. Thus, T 2 time courses were comparable between GM and WM independent of brain tissue type involved. We demonstrate that T 2 changes in ADC-delineated lesions can be quantified in the clinical setting in a user unbiased manner and that T 2 change correlated with symptom onset time, opening the possibility of using the approach as a tool to assess severity of tissue damage in the clinical setting.</p> |
| first_indexed | 2024-03-06T19:57:35Z |
| format | Journal article |
| id | oxford-uuid:262b38de-b80f-411b-819e-4fd65aca0bad |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:57:35Z |
| publishDate | 2019 |
| publisher | IOP Publishing |
| record_format | dspace |
| spelling | oxford-uuid:262b38de-b80f-411b-819e-4fd65aca0bad2022-03-26T11:59:25ZQuantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patientsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:262b38de-b80f-411b-819e-4fd65aca0badEnglishSymplectic Elements at OxfordIOP Publishing2019Damion, RKnight, MMcGarry, BBosnell, RJezzard, PHarston, GCarone, DKennedy, JEl-Tawil, SElliot, JMuir, KClatworthy, PKauppinen, R<p>The apparent diffusion coefficient (ADC) of cerebral water, as measured by diffusion MRI, rapidly decreases in ischaemia, highlighting a lesion in acute stroke patients. The MRI T 2 relaxation time changes in ischaemic brain such that T 2 in ADC lesions may be informative of the extent of tissue damage, potentially aiding in stratification for treatment. We have developed a novel user-unbiased method of determining the changes in T 2 in ADC lesions as a function of clinical symptom duration based on voxel-wise referencing to a contralateral brain volume. The spherical reference method calculates the most probable pre-ischaemic T 2 on a voxel-wise basis, making use of features of the contralateral hemisphere presumed to be largely unaffected. We studied whether T 2 changes in the two main cerebral tissue types, i.e. in grey matter (GM) and white matter (WM), would differ in stroke.</p><br/> <p>Thirty-eight acute stroke patients were accrued within 9 h of symptom onset and scanned at 3 T for 3D T 1-weighted, multi b-value diffusion and multi-echo spin echo MRI for tissue type segmentation, quantitative ADC and absolute T 2 images, respectively. T 2 changes measured by the spherical reference method were 1.94 ± 0.61, 1.50 ± 0.52 and 1.40 ± 0.54 ms h−1 in the whole, GM, and WM lesions, respectively. Thus, T 2 time courses were comparable between GM and WM independent of brain tissue type involved. We demonstrate that T 2 changes in ADC-delineated lesions can be quantified in the clinical setting in a user unbiased manner and that T 2 change correlated with symptom onset time, opening the possibility of using the approach as a tool to assess severity of tissue damage in the clinical setting.</p> |
| spellingShingle | Damion, R Knight, M McGarry, B Bosnell, R Jezzard, P Harston, G Carone, D Kennedy, J El-Tawil, S Elliot, J Muir, K Clatworthy, P Kauppinen, R Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients |
| title | Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients |
| title_full | Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients |
| title_fullStr | Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients |
| title_full_unstemmed | Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients |
| title_short | Quantifying T2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients |
| title_sort | quantifying t2 relaxation time changes within lesions defined by apparent diffusion coefficient in grey and white matter in acute stroke patients |
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