Myosin sequestration regulates sarcomere function, cardiomyocyte energetics, and metabolism, informing the pathogenesis of hypertrophic cardiomyopathy

Myosin sequestration regulates sarcomere function, cardiomyocyte energetics, and metabolism, informing the pathogenesis of hypertrophic cardiomyopathy

<p><strong>Background:</strong> Hypertrophic cardiomyopathy (HCM) is caused by pathogenic variants in sarcomere protein genes that evoke hypercontractility, poor relaxation, and increased energy consumption by the heart and increased patient risks for arrhythmias and heart failure....

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Main Authors: Toepfer, CN, Garfinkel, AC, Venturini, G, Wakimoto, H, Repetti, G, Alamo, L, Sharma, A, Agarwal, R, Ewoldt, JF, Cloonan, P, Letendre, J, Lun, M, Olivotto, I, Colan, S, Ashley, E, Jacoby, D, Michels, M, Redwood, CS, Watkins, HC, Day, SM, Staples, JF, Padrón, R, Chopra, A, Ho, CY, Chen, CS, Pereira, AC, Seidman, JG, Seidman, CE
格式: Journal article
语言:English
出版: American Heart Association 2020

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