Identification of the target self-antigens in reperfusion injury.
Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of n...
| Päätekijät: | , , , , , , , , , , , , , |
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| Aineistotyyppi: | Journal article |
| Kieli: | English |
| Julkaistu: |
2006
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| _version_ | 1826263804896346112 |
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| author | Zhang, M Alicot, E Chiu, I Li, J Verna, N Vorup-Jensen, T Kessler, B Shimaoka, M Chan, R Friend, D Mahmood, U Weissleder, R Moore, F Carroll, M |
| author_facet | Zhang, M Alicot, E Chiu, I Li, J Verna, N Vorup-Jensen, T Kessler, B Shimaoka, M Chan, R Friend, D Mahmood, U Weissleder, R Moore, F Carroll, M |
| author_sort | Zhang, M |
| collection | OXFORD |
| description | Reperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction. |
| first_indexed | 2024-03-06T19:57:41Z |
| format | Journal article |
| id | oxford-uuid:26340777-4ce4-4aa6-96f7-17745e96d9b2 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:57:41Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:26340777-4ce4-4aa6-96f7-17745e96d9b22022-03-26T11:59:36ZIdentification of the target self-antigens in reperfusion injury.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:26340777-4ce4-4aa6-96f7-17745e96d9b2EnglishSymplectic Elements at Oxford2006Zhang, MAlicot, EChiu, ILi, JVerna, NVorup-Jensen, TKessler, BShimaoka, MChan, RFriend, DMahmood, UWeissleder, RMoore, FCarroll, MReperfusion injury (RI), a potential life-threatening disorder, represents an acute inflammatory response after periods of ischemia resulting from myocardial infarction, stroke, surgery, or trauma. The recent identification of a monoclonal natural IgM that initiates RI led to the identification of nonmuscle myosin heavy chain type II A and C as the self-targets in two different tissues. These results identify a novel pathway in which the innate response to a highly conserved self-antigen expressed as a result of hypoxic stress results in tissue destruction. |
| spellingShingle | Zhang, M Alicot, E Chiu, I Li, J Verna, N Vorup-Jensen, T Kessler, B Shimaoka, M Chan, R Friend, D Mahmood, U Weissleder, R Moore, F Carroll, M Identification of the target self-antigens in reperfusion injury. |
| title | Identification of the target self-antigens in reperfusion injury. |
| title_full | Identification of the target self-antigens in reperfusion injury. |
| title_fullStr | Identification of the target self-antigens in reperfusion injury. |
| title_full_unstemmed | Identification of the target self-antigens in reperfusion injury. |
| title_short | Identification of the target self-antigens in reperfusion injury. |
| title_sort | identification of the target self antigens in reperfusion injury |
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