Mutate and conjugate: a method to enable rapid in-cell target validation

Target validation remains a challenge in drug discovery, which leads to a high attrition rate in the drug discovery process, particularly in Phase II clinical trials. Consequently, new approaches to enhance target validation are valuable tools to improve the drug discovery process. Here, we report t...

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Bibliographic Details
Main Authors: Thomas, AM, Serafini, M, Grant, EK, Coombs, EAJ, Bluck, JP, Schiedel, M, McDonough, MA, Reynolds, JK, Lee, B, Platt, M, Sharlandjieva, V, Biggin, PC, Duarte, F, Milne, TA, Bush, JT, Conway, SJ
Format: Journal article
Language:English
Published: American Chemical Society 2023