Investigation of pharmacological and physiological regulation of pyruvate dehydrogenase in diabetes using hyperpolarised magnetic resonance spectroscopy

<p>In type II diabetes, systemic metabolism is perturbed and on a cellular level the balance of fuel use is upset. More specifically, increased fatty acid use is seen alongside decreased glucose metabolism. This altered fuel use is mediated by changes in the activity and expression of multipl...

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Bibliographic Details
Main Author: Le Page, L
Other Authors: Tyler, D
Format: Thesis
Language:English
Published: 2014
Subjects: