Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages
Oligonucleotides hold great promise as therapeutic agents but poor bioavailability limits their utility. Hence, new analogues with improved cell uptake are urgently needed. Here, we report the synthesis and physical study of reduced-charge oligonucleotides containing artificial LNA-sulfamate and sul...
| Main Authors: | , , , |
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| Format: | Journal article |
| Language: | English |
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American Chemical Society
2024
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| _version_ | 1811140101189664768 |
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| author | Zengin Kurt, B Dhara, D El-Sagheer, AH Brown, T |
| author_facet | Zengin Kurt, B Dhara, D El-Sagheer, AH Brown, T |
| author_sort | Zengin Kurt, B |
| collection | OXFORD |
| description | Oligonucleotides hold great promise as therapeutic agents but poor bioavailability limits their utility. Hence, new analogues with improved cell uptake are urgently needed. Here, we report the synthesis and physical study of reduced-charge oligonucleotides containing artificial LNA-sulfamate and sulfamide linkages combined with 2′-O-methyl sugars and phosphorothioate backbones. These oligonucleotides have high affinity for RNA and excellent nuclease resistance. |
| first_indexed | 2024-09-25T04:16:37Z |
| format | Journal article |
| id | oxford-uuid:2686c0d3-d8a8-4d46-a70d-bfa746af5b82 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-09-25T04:16:37Z |
| publishDate | 2024 |
| publisher | American Chemical Society |
| record_format | dspace |
| spelling | oxford-uuid:2686c0d3-d8a8-4d46-a70d-bfa746af5b822024-07-20T15:48:16ZSynthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone LinkagesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2686c0d3-d8a8-4d46-a70d-bfa746af5b82EnglishJisc Publications RouterAmerican Chemical Society2024Zengin Kurt, BDhara, DEl-Sagheer, AHBrown, TOligonucleotides hold great promise as therapeutic agents but poor bioavailability limits their utility. Hence, new analogues with improved cell uptake are urgently needed. Here, we report the synthesis and physical study of reduced-charge oligonucleotides containing artificial LNA-sulfamate and sulfamide linkages combined with 2′-O-methyl sugars and phosphorothioate backbones. These oligonucleotides have high affinity for RNA and excellent nuclease resistance. |
| spellingShingle | Zengin Kurt, B Dhara, D El-Sagheer, AH Brown, T Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages |
| title | Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages |
| title_full | Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages |
| title_fullStr | Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages |
| title_full_unstemmed | Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages |
| title_short | Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages |
| title_sort | synthesis and properties of oligonucleotides containing lna sulfamate and sulfamide backbone linkages |
| work_keys_str_mv | AT zenginkurtb synthesisandpropertiesofoligonucleotidescontaininglnasulfamateandsulfamidebackbonelinkages AT dharad synthesisandpropertiesofoligonucleotidescontaininglnasulfamateandsulfamidebackbonelinkages AT elsagheerah synthesisandpropertiesofoligonucleotidescontaininglnasulfamateandsulfamidebackbonelinkages AT brownt synthesisandpropertiesofoligonucleotidescontaininglnasulfamateandsulfamidebackbonelinkages |