Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages

Synthesis and Properties of Oligonucleotides Containing LNA-Sulfamate and Sulfamide Backbone Linkages

Oligonucleotides hold great promise as therapeutic agents but poor bioavailability limits their utility. Hence, new analogues with improved cell uptake are urgently needed. Here, we report the synthesis and physical study of reduced-charge oligonucleotides containing artificial LNA-sulfamate and sul...

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Bibliographic Details
Main Authors:	Zengin Kurt, B, Dhara, D, El-Sagheer, AH, Brown, T
Format:	Journal article
Language:	English
Published:	American Chemical Society 2024

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