Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications
Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation of ATP but it is now clear that OXPHOS, at lea...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2022
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| _version_ | 1797110269178019840 |
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| author | Greene, J Segaran, A Lord, S |
| author_facet | Greene, J Segaran, A Lord, S |
| author_sort | Greene, J |
| collection | OXFORD |
| description | Oxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation of ATP but it is now clear that OXPHOS, at least in many tumour types, plays a critical role in delivering the bioenergetic and macromolecular anabolic requirements of cancer cells. There is now great interest in targeting the OXPHOS and the electron transport chain for cancer therapy and in this review article we describe current therapeutic approaches and challenges. |
| first_indexed | 2024-03-07T07:52:33Z |
| format | Journal article |
| id | oxford-uuid:268d0a0b-730c-4ba8-a6a1-9c9cde7ea92f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:52:33Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:268d0a0b-730c-4ba8-a6a1-9c9cde7ea92f2023-08-02T11:12:53ZTargeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implicationsJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:268d0a0b-730c-4ba8-a6a1-9c9cde7ea92fEnglishSymplectic ElementsElsevier2022Greene, JSegaran, ALord, SOxidative phosphorylation (OXPHOS) takes place in mitochondria and is the process whereby cells use carbon fuels and oxygen to generate ATP. Formerly OXPHOS was thought to be reduced in tumours and that glycolysis was the critical pathway for generation of ATP but it is now clear that OXPHOS, at least in many tumour types, plays a critical role in delivering the bioenergetic and macromolecular anabolic requirements of cancer cells. There is now great interest in targeting the OXPHOS and the electron transport chain for cancer therapy and in this review article we describe current therapeutic approaches and challenges. |
| spellingShingle | Greene, J Segaran, A Lord, S Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications |
| title | Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications |
| title_full | Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications |
| title_fullStr | Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications |
| title_full_unstemmed | Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications |
| title_short | Targeting OXPHOS and the electron transport chain in cancer; molecular and therapeutic implications |
| title_sort | targeting oxphos and the electron transport chain in cancer molecular and therapeutic implications |
| work_keys_str_mv | AT greenej targetingoxphosandtheelectrontransportchainincancermolecularandtherapeuticimplications AT segarana targetingoxphosandtheelectrontransportchainincancermolecularandtherapeuticimplications AT lords targetingoxphosandtheelectrontransportchainincancermolecularandtherapeuticimplications |