Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlappi...
| Главные авторы: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Формат: | Journal article |
| Язык: | English |
| Опубликовано: |
Elsevier
2015
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| _version_ | 1826263891593658368 |
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| author | Guerreiro, R Escott-Price, V Darwent, L Parkkinen, L Ansorge, O Hernandez, D Nalls, M Clark, L Honig, L Marder, K Van Der Flier, W Holstege, H Louwersheimer, E Lemstra, A Scheltens, P Rogaeva, E St George-Hyslop, P Londos, E Zetterberg, H Ortega-Cubero, S Pastor, P Ferman, T Graff-Radford, N Ross, O Barber, I Braae, A Brown, K Morgan, K Maetzler, W Berg, D Troakes, C Al-Sarraj, S Lashley, T Compta, Y Revesz, T Lees, A Cairns, N Halliday, G Mann, D Pickering-Brown, S Powell, J Lunnon, K Lupton, M Dickson, D Hardy, J Singleton, A Bras, J |
| author_facet | Guerreiro, R Escott-Price, V Darwent, L Parkkinen, L Ansorge, O Hernandez, D Nalls, M Clark, L Honig, L Marder, K Van Der Flier, W Holstege, H Louwersheimer, E Lemstra, A Scheltens, P Rogaeva, E St George-Hyslop, P Londos, E Zetterberg, H Ortega-Cubero, S Pastor, P Ferman, T Graff-Radford, N Ross, O Barber, I Braae, A Brown, K Morgan, K Maetzler, W Berg, D Troakes, C Al-Sarraj, S Lashley, T Compta, Y Revesz, T Lees, A Cairns, N Halliday, G Mann, D Pickering-Brown, S Powell, J Lunnon, K Lupton, M Dickson, D Hardy, J Singleton, A Bras, J |
| author_sort | Guerreiro, R |
| collection | OXFORD |
| description | The similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
| first_indexed | 2024-03-06T19:59:10Z |
| format | Journal article |
| id | oxford-uuid:26a772c0-1100-43d0-8835-de14ef2415e1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:59:10Z |
| publishDate | 2015 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:26a772c0-1100-43d0-8835-de14ef2415e12022-03-26T12:02:22ZGenome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseasesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:26a772c0-1100-43d0-8835-de14ef2415e1EnglishSymplectic Elements at OxfordElsevier2015Guerreiro, REscott-Price, VDarwent, LParkkinen, LAnsorge, OHernandez, DNalls, MClark, LHonig, LMarder, KVan Der Flier, WHolstege, HLouwersheimer, ELemstra, AScheltens, PRogaeva, ESt George-Hyslop, PLondos, EZetterberg, HOrtega-Cubero, SPastor, PFerman, TGraff-Radford, NRoss, OBarber, IBraae, ABrown, KMorgan, KMaetzler, WBerg, DTroakes, CAl-Sarraj, SLashley, TCompta, YRevesz, TLees, ACairns, NHalliday, GMann, DPickering-Brown, SPowell, JLunnon, KLupton, MDickson, DHardy, JSingleton, ABras, JThe similarities between dementia with Lewy bodies (DLB) and both Parkinson's disease (PD) and Alzheimer's disease (AD) are many and range from clinical presentation, to neuropathological characteristics, to more recently identified, genetic determinants of risk. Because of these overlapping features, diagnosing DLB is challenging and has clinical implications since some therapeutic agents that are applicable in other diseases have adverse effects in DLB. Having shown that DLB shares some genetic risk with PD and AD, we have now quantified the amount of sharing through the application of genetic correlation estimates, and show that, from a purely genetic perspective, and excluding the strong association at the APOE locus, DLB is equally correlated to AD and PD. |
| spellingShingle | Guerreiro, R Escott-Price, V Darwent, L Parkkinen, L Ansorge, O Hernandez, D Nalls, M Clark, L Honig, L Marder, K Van Der Flier, W Holstege, H Louwersheimer, E Lemstra, A Scheltens, P Rogaeva, E St George-Hyslop, P Londos, E Zetterberg, H Ortega-Cubero, S Pastor, P Ferman, T Graff-Radford, N Ross, O Barber, I Braae, A Brown, K Morgan, K Maetzler, W Berg, D Troakes, C Al-Sarraj, S Lashley, T Compta, Y Revesz, T Lees, A Cairns, N Halliday, G Mann, D Pickering-Brown, S Powell, J Lunnon, K Lupton, M Dickson, D Hardy, J Singleton, A Bras, J Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_full | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_fullStr | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_full_unstemmed | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_short | Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases |
| title_sort | genome wide analysis of genetic correlation in dementia with lewy bodies parkinson s and alzheimer s diseases |
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