The functions of microparticles in pre-eclampsia.
Pre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is un...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797059108714577920 |
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| author | van der Post, J Lok, C Boer, K Sturk, A Sargent, I Nieuwland, R |
| author_facet | van der Post, J Lok, C Boer, K Sturk, A Sargent, I Nieuwland, R |
| author_sort | van der Post, J |
| collection | OXFORD |
| description | Pre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is unknown, placental factors released into the maternal circulation lead to systemic maternal inflammation and endothelial dysfunction. Growing evidence indicates that placenta-derived microparticles, best known as syncytiotrophoblast microparticles (STBM), are important among these factors. This review provides an overview of the presence and function(s) of STBM and other cell-derived microparticles and exosomes. |
| first_indexed | 2024-03-06T19:59:32Z |
| format | Journal article |
| id | oxford-uuid:26c9c377-f03d-4cfa-9d1b-f565d0b6d4eb |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:59:32Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:26c9c377-f03d-4cfa-9d1b-f565d0b6d4eb2022-03-26T12:03:15ZThe functions of microparticles in pre-eclampsia.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:26c9c377-f03d-4cfa-9d1b-f565d0b6d4ebEnglishSymplectic Elements at Oxford2011van der Post, JLok, CBoer, KSturk, ASargent, INieuwland, RPre-eclampsia (P-EC), a heterogenic multisystem disorder characterized by hypertension and proteinuria, usually develops in the second half of pregnancy. The incidence is 2 to 5%, and P-EC is therefore a major cause of maternal and perinatal morbidity and mortality. Although the exact etiology is unknown, placental factors released into the maternal circulation lead to systemic maternal inflammation and endothelial dysfunction. Growing evidence indicates that placenta-derived microparticles, best known as syncytiotrophoblast microparticles (STBM), are important among these factors. This review provides an overview of the presence and function(s) of STBM and other cell-derived microparticles and exosomes. |
| spellingShingle | van der Post, J Lok, C Boer, K Sturk, A Sargent, I Nieuwland, R The functions of microparticles in pre-eclampsia. |
| title | The functions of microparticles in pre-eclampsia. |
| title_full | The functions of microparticles in pre-eclampsia. |
| title_fullStr | The functions of microparticles in pre-eclampsia. |
| title_full_unstemmed | The functions of microparticles in pre-eclampsia. |
| title_short | The functions of microparticles in pre-eclampsia. |
| title_sort | functions of microparticles in pre eclampsia |
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