Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome.
Serial muscle biopsies in a noncarcinomatous case of Lambert-Eaton myasthenic syndrome (LEMS) have shown progressive atrophy and loss of type 1 fibers, resulting in overwhelming type 2 predominance. A similar abnormality was found in a single biopsy from a second case of LEMS without associated carc...
| Main Authors: | , , , , |
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| Format: | Journal article |
| Language: | English |
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1991
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| _version_ | 1826263923384385536 |
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| author | Squier, M Chalk, C Hilton-Jones, D Mills, K Newsom-Davis, J |
| author_facet | Squier, M Chalk, C Hilton-Jones, D Mills, K Newsom-Davis, J |
| author_sort | Squier, M |
| collection | OXFORD |
| description | Serial muscle biopsies in a noncarcinomatous case of Lambert-Eaton myasthenic syndrome (LEMS) have shown progressive atrophy and loss of type 1 fibers, resulting in overwhelming type 2 predominance. A similar abnormality was found in a single biopsy from a second case of LEMS without associated carcinoma. Review of the literature suggests that type 2 fiber predominance has been observed in at least one other biopsied case. Interference with transmitter release caused by anti-voltage-gated calcium channel antibodies may deprive type 1 muscle fibers of the low frequency discharge necessary to maintain their metabolic properties. |
| first_indexed | 2024-03-06T19:59:35Z |
| format | Journal article |
| id | oxford-uuid:26cf3486-8a71-4f6b-b18b-9e591173fdf7 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:59:35Z |
| publishDate | 1991 |
| record_format | dspace |
| spelling | oxford-uuid:26cf3486-8a71-4f6b-b18b-9e591173fdf72022-03-26T12:03:18ZType 2 fiber predominance in Lambert-Eaton myasthenic syndrome.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:26cf3486-8a71-4f6b-b18b-9e591173fdf7EnglishSymplectic Elements at Oxford1991Squier, MChalk, CHilton-Jones, DMills, KNewsom-Davis, JSerial muscle biopsies in a noncarcinomatous case of Lambert-Eaton myasthenic syndrome (LEMS) have shown progressive atrophy and loss of type 1 fibers, resulting in overwhelming type 2 predominance. A similar abnormality was found in a single biopsy from a second case of LEMS without associated carcinoma. Review of the literature suggests that type 2 fiber predominance has been observed in at least one other biopsied case. Interference with transmitter release caused by anti-voltage-gated calcium channel antibodies may deprive type 1 muscle fibers of the low frequency discharge necessary to maintain their metabolic properties. |
| spellingShingle | Squier, M Chalk, C Hilton-Jones, D Mills, K Newsom-Davis, J Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. |
| title | Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. |
| title_full | Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. |
| title_fullStr | Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. |
| title_full_unstemmed | Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. |
| title_short | Type 2 fiber predominance in Lambert-Eaton myasthenic syndrome. |
| title_sort | type 2 fiber predominance in lambert eaton myasthenic syndrome |
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