Identification of scavenger receptor ligands.
Scavenger receptors (SRs) are structurally diverse but functionally related innate immune receptors involved in defence and clearance mechanisms. Their broad specificity relies on evolutionarily conserved pattern recognition domains which interact with a variety of microbial, apoptotic and modified...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2011
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| _version_ | 1797059119425781760 |
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| author | Neyen, C Pluddemann, A Gordon, S |
| author_facet | Neyen, C Pluddemann, A Gordon, S |
| author_sort | Neyen, C |
| collection | OXFORD |
| description | Scavenger receptors (SRs) are structurally diverse but functionally related innate immune receptors involved in defence and clearance mechanisms. Their broad specificity relies on evolutionarily conserved pattern recognition domains which interact with a variety of microbial, apoptotic and modified self ligands. Studies of immune functions of SR-expressing cells require the identification of interaction partners for SRs. We have developed an ELISA-based method which allows for large-scale high-throughput screening of complex mixtures. The assay successfully identified bacterial and plasma ligands for macrophage scavenger receptor A and can be adapted to screen for novel exogenous or endogenous ligands for any immune receptor of interest. |
| first_indexed | 2024-03-06T19:59:41Z |
| format | Journal article |
| id | oxford-uuid:26d7a1f8-9fad-4165-ac05-ed49191bae9b |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:59:41Z |
| publishDate | 2011 |
| record_format | dspace |
| spelling | oxford-uuid:26d7a1f8-9fad-4165-ac05-ed49191bae9b2022-03-26T12:03:28ZIdentification of scavenger receptor ligands.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:26d7a1f8-9fad-4165-ac05-ed49191bae9bEnglishSymplectic Elements at Oxford2011Neyen, CPluddemann, AGordon, SScavenger receptors (SRs) are structurally diverse but functionally related innate immune receptors involved in defence and clearance mechanisms. Their broad specificity relies on evolutionarily conserved pattern recognition domains which interact with a variety of microbial, apoptotic and modified self ligands. Studies of immune functions of SR-expressing cells require the identification of interaction partners for SRs. We have developed an ELISA-based method which allows for large-scale high-throughput screening of complex mixtures. The assay successfully identified bacterial and plasma ligands for macrophage scavenger receptor A and can be adapted to screen for novel exogenous or endogenous ligands for any immune receptor of interest. |
| spellingShingle | Neyen, C Pluddemann, A Gordon, S Identification of scavenger receptor ligands. |
| title | Identification of scavenger receptor ligands. |
| title_full | Identification of scavenger receptor ligands. |
| title_fullStr | Identification of scavenger receptor ligands. |
| title_full_unstemmed | Identification of scavenger receptor ligands. |
| title_short | Identification of scavenger receptor ligands. |
| title_sort | identification of scavenger receptor ligands |
| work_keys_str_mv | AT neyenc identificationofscavengerreceptorligands AT pluddemanna identificationofscavengerreceptorligands AT gordons identificationofscavengerreceptorligands |