Pain vulnerability: a neurobiological perspective.
There are many known risk factors for chronic pain conditions, yet the biological underpinnings that link these factors to abnormal processing of painful signals are only just beginning to be explored. This Review will discuss the potential mechanisms that have been proposed to underlie vulnerabilit...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
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2014
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| _version_ | 1797059122515935232 |
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| author | Denk, F McMahon, S Tracey, I |
| author_facet | Denk, F McMahon, S Tracey, I |
| author_sort | Denk, F |
| collection | OXFORD |
| description | There are many known risk factors for chronic pain conditions, yet the biological underpinnings that link these factors to abnormal processing of painful signals are only just beginning to be explored. This Review will discuss the potential mechanisms that have been proposed to underlie vulnerability and resilience toward developing chronic pain. Particular focus will be given to genetic and epigenetic processes, priming effects on a cellular level, and alterations in brain networks concerned with reward, motivation/learning and descending modulatory control. Although research in this area is still in its infancy, a better understanding of how pain vulnerability emerges has the potential to help identify individuals at risk and may open up new therapeutic avenues. |
| first_indexed | 2024-03-06T19:59:44Z |
| format | Journal article |
| id | oxford-uuid:26dbc7ea-909f-4ff9-82de-45b6ad53067f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T19:59:44Z |
| publishDate | 2014 |
| record_format | dspace |
| spelling | oxford-uuid:26dbc7ea-909f-4ff9-82de-45b6ad53067f2022-03-26T12:03:32ZPain vulnerability: a neurobiological perspective.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:26dbc7ea-909f-4ff9-82de-45b6ad53067fEnglishSymplectic Elements at Oxford2014Denk, FMcMahon, STracey, IThere are many known risk factors for chronic pain conditions, yet the biological underpinnings that link these factors to abnormal processing of painful signals are only just beginning to be explored. This Review will discuss the potential mechanisms that have been proposed to underlie vulnerability and resilience toward developing chronic pain. Particular focus will be given to genetic and epigenetic processes, priming effects on a cellular level, and alterations in brain networks concerned with reward, motivation/learning and descending modulatory control. Although research in this area is still in its infancy, a better understanding of how pain vulnerability emerges has the potential to help identify individuals at risk and may open up new therapeutic avenues. |
| spellingShingle | Denk, F McMahon, S Tracey, I Pain vulnerability: a neurobiological perspective. |
| title | Pain vulnerability: a neurobiological perspective. |
| title_full | Pain vulnerability: a neurobiological perspective. |
| title_fullStr | Pain vulnerability: a neurobiological perspective. |
| title_full_unstemmed | Pain vulnerability: a neurobiological perspective. |
| title_short | Pain vulnerability: a neurobiological perspective. |
| title_sort | pain vulnerability a neurobiological perspective |
| work_keys_str_mv | AT denkf painvulnerabilityaneurobiologicalperspective AT mcmahons painvulnerabilityaneurobiologicalperspective AT traceyi painvulnerabilityaneurobiologicalperspective |