Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.

Anticancer DNA intercalators cause p53-dependent mitochondrial DNA nucleoid re-modelling.

Many anticancer drugs, such as doxorubicin (DXR), intercalate into nuclear DNA of cancer cells, thereby inhibiting their growth. However, it is not well understood how such drugs interact with mitochondrial DNA (mtDNA). Using cell and molecular studies of cultured cells, we show that DXR and other D...

书目详细资料
Main Authors:	Ashley, N, Poulton, J
格式:	Journal article
语言:	English
出版:	2009

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