Sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK Biobank
<p><em>Background: </em>There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex-specific relationships, and their differences, between measures of general and central adiposity and the risk of incident MI.</p> <p&g...
| Main Authors: | , , |
|---|---|
| Format: | Journal article |
| Izdano: |
American Heart Association
2018
|
| _version_ | 1826263943267483648 |
|---|---|
| author | Peters, S Bots, S Woodward, M |
| author_facet | Peters, S Bots, S Woodward, M |
| author_sort | Peters, S |
| collection | OXFORD |
| description | <p><em>Background: </em>There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex-specific relationships, and their differences, between measures of general and central adiposity and the risk of incident MI.</p> <p><em>Methods and results: </em>Between 2006-10, the UK Biobank recruited over 500,000 participants aged 40-69 years across the UK. During 7 years of follow-up, 5,710 cases of MI (28% women) were recorded among 265,988 women and 213,622 men without a history of cardiovascular disease at baseline. Cox regression models yielded adjusted hazard ratios (HRs) for MI associated with body mass index (BMI), waist circumference, waist-to-hip ratio, and waist-to-height ratio. There was an approximate log-linear relationship between measures of general and central adiposity and the risk of MI in both sexes. A 1-SD increase in BMI, waist circumference, waist-to-hip ratio, and waist-to-height ratio, respectively, were associated with HRs for MI of 1.22 (1.17; 1.28), 1.35 (1.28; 1.42), 1.49 (1.39; 1.59), 1.34 (1.27; 1.40) in women and of 1.28 (1.23; 1.32), 1.28 (1.23; 1.33), 1.36 (1.30; 1.43), and 1.33 (1.28; 1.38) in men. The corresponding women-to-men ratio of HRs were 0.96 (0.91; 1.02), 1.07 (1.00; 1.14), 1.15 (1.06; 1.24), and 1.03 (0.97; 1.09).</p> <p><em>Conclusion: </em>While general and central adiposity measures each have profound deleterious effects on the risk of MI in both sexes, increases in waist circumference and waist-to-hip ratio conferred a greater excess risk of MI in women than men. Waist-to-hip ratio was more strongly associated with the risk of MI than BMI in both sexes, especially in women.</p> |
| first_indexed | 2024-03-06T19:59:54Z |
| format | Journal article |
| id | oxford-uuid:26e95f83-20c5-47b5-bf88-514ece52b2f0 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T19:59:54Z |
| publishDate | 2018 |
| publisher | American Heart Association |
| record_format | dspace |
| spelling | oxford-uuid:26e95f83-20c5-47b5-bf88-514ece52b2f02022-03-26T12:03:52ZSex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK BiobankJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:26e95f83-20c5-47b5-bf88-514ece52b2f0Symplectic Elements at OxfordAmerican Heart Association2018Peters, SBots, SWoodward, M<p><em>Background: </em>There are substantial differences in the distribution of adipose tissue between women and men. We assessed the sex-specific relationships, and their differences, between measures of general and central adiposity and the risk of incident MI.</p> <p><em>Methods and results: </em>Between 2006-10, the UK Biobank recruited over 500,000 participants aged 40-69 years across the UK. During 7 years of follow-up, 5,710 cases of MI (28% women) were recorded among 265,988 women and 213,622 men without a history of cardiovascular disease at baseline. Cox regression models yielded adjusted hazard ratios (HRs) for MI associated with body mass index (BMI), waist circumference, waist-to-hip ratio, and waist-to-height ratio. There was an approximate log-linear relationship between measures of general and central adiposity and the risk of MI in both sexes. A 1-SD increase in BMI, waist circumference, waist-to-hip ratio, and waist-to-height ratio, respectively, were associated with HRs for MI of 1.22 (1.17; 1.28), 1.35 (1.28; 1.42), 1.49 (1.39; 1.59), 1.34 (1.27; 1.40) in women and of 1.28 (1.23; 1.32), 1.28 (1.23; 1.33), 1.36 (1.30; 1.43), and 1.33 (1.28; 1.38) in men. The corresponding women-to-men ratio of HRs were 0.96 (0.91; 1.02), 1.07 (1.00; 1.14), 1.15 (1.06; 1.24), and 1.03 (0.97; 1.09).</p> <p><em>Conclusion: </em>While general and central adiposity measures each have profound deleterious effects on the risk of MI in both sexes, increases in waist circumference and waist-to-hip ratio conferred a greater excess risk of MI in women than men. Waist-to-hip ratio was more strongly associated with the risk of MI than BMI in both sexes, especially in women.</p> |
| spellingShingle | Peters, S Bots, S Woodward, M Sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK Biobank |
| title | Sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK Biobank |
| title_full | Sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK Biobank |
| title_fullStr | Sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK Biobank |
| title_full_unstemmed | Sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK Biobank |
| title_short | Sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction: results from the UK Biobank |
| title_sort | sex differences in the association between measures of general and central adiposity and the risk of myocardial infarction results from the uk biobank |
| work_keys_str_mv | AT peterss sexdifferencesintheassociationbetweenmeasuresofgeneralandcentraladiposityandtheriskofmyocardialinfarctionresultsfromtheukbiobank AT botss sexdifferencesintheassociationbetweenmeasuresofgeneralandcentraladiposityandtheriskofmyocardialinfarctionresultsfromtheukbiobank AT woodwardm sexdifferencesintheassociationbetweenmeasuresofgeneralandcentraladiposityandtheriskofmyocardialinfarctionresultsfromtheukbiobank |