Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1).
Brain-specific angiogenesis inhibitor 1 (BAI1) is a novel angioinhibitory factor. We examined BAI1 gene expression in 48 pulmonary adenocarcinoma specimens by RT-PCR. Vascular density (number and measurement area) was immunohistochemically evaluated in tumor specimens using anti-CD34 monoclonal anti...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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2000
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| _version_ | 1826263962731151360 |
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| author | Hatanaka, H Oshika, Y Abe, Y Yoshida, Y Hashimoto, T Handa, A Kijima, H Yamazaki, H Inoue, H Ueyama, Y Nakamura, M |
| author_facet | Hatanaka, H Oshika, Y Abe, Y Yoshida, Y Hashimoto, T Handa, A Kijima, H Yamazaki, H Inoue, H Ueyama, Y Nakamura, M |
| author_sort | Hatanaka, H |
| collection | OXFORD |
| description | Brain-specific angiogenesis inhibitor 1 (BAI1) is a novel angioinhibitory factor. We examined BAI1 gene expression in 48 pulmonary adenocarcinoma specimens by RT-PCR. Vascular density (number and measurement area) was immunohistochemically evaluated in tumor specimens using anti-CD34 monoclonal antibody. BAI1 gene expression was detected in 38 of 48 pulmonary adenocarcinomas (79. 2%). Vascular number and measurement area were significantly decreased in the BAI1-positive pulmonary adenocarcinomas (19.3+/-4. 4/microm2 and 1.7+/-0.6%) as compared with those in the BAI1-negative carcinomas (75.5+/-42.7/microm2 and 5.5+/-1.5%) (Mann-Whitney U-test, p=0.0017). These results suggest that BAI1 expression may inhibit stromal vascularization in pulmonary adenocarcinoma. |
| first_indexed | 2024-03-06T20:00:13Z |
| format | Journal article |
| id | oxford-uuid:270a5268-7be0-4bec-b459-e93a660214e4 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:00:13Z |
| publishDate | 2000 |
| record_format | dspace |
| spelling | oxford-uuid:270a5268-7be0-4bec-b459-e93a660214e42022-03-26T12:04:31ZVascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1).Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:270a5268-7be0-4bec-b459-e93a660214e4EnglishSymplectic Elements at Oxford2000Hatanaka, HOshika, YAbe, YYoshida, YHashimoto, THanda, AKijima, HYamazaki, HInoue, HUeyama, YNakamura, MBrain-specific angiogenesis inhibitor 1 (BAI1) is a novel angioinhibitory factor. We examined BAI1 gene expression in 48 pulmonary adenocarcinoma specimens by RT-PCR. Vascular density (number and measurement area) was immunohistochemically evaluated in tumor specimens using anti-CD34 monoclonal antibody. BAI1 gene expression was detected in 38 of 48 pulmonary adenocarcinomas (79. 2%). Vascular number and measurement area were significantly decreased in the BAI1-positive pulmonary adenocarcinomas (19.3+/-4. 4/microm2 and 1.7+/-0.6%) as compared with those in the BAI1-negative carcinomas (75.5+/-42.7/microm2 and 5.5+/-1.5%) (Mann-Whitney U-test, p=0.0017). These results suggest that BAI1 expression may inhibit stromal vascularization in pulmonary adenocarcinoma. |
| spellingShingle | Hatanaka, H Oshika, Y Abe, Y Yoshida, Y Hashimoto, T Handa, A Kijima, H Yamazaki, H Inoue, H Ueyama, Y Nakamura, M Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). |
| title | Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). |
| title_full | Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). |
| title_fullStr | Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). |
| title_full_unstemmed | Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). |
| title_short | Vascularization is decreased in pulmonary adenocarcinoma expressing brain-specific angiogenesis inhibitor 1 (BAI1). |
| title_sort | vascularization is decreased in pulmonary adenocarcinoma expressing brain specific angiogenesis inhibitor 1 bai1 |
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