Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes
<p>We evaluated the impact of 6-month probiotics and calcium supplementation at 1–6 years of age on neurodevelopment in adolescence, along with the effects of other biomedical and socioenvironmental factors. We re-enrolled 238 adolescents 10-years after supplementation with low-lacto...
| Main Authors: | , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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Elsevier
2022
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| _version_ | 1797106345647800320 |
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| author | Rianda, D Suradijono, SHR Setiawan, EA Susanto, F Meilianawati, M Prafiantini, E Kok, FJ Shankar, AH Agustina, R |
| author_facet | Rianda, D Suradijono, SHR Setiawan, EA Susanto, F Meilianawati, M Prafiantini, E Kok, FJ Shankar, AH Agustina, R |
| author_sort | Rianda, D |
| collection | OXFORD |
| description | <p>We evaluated the impact of 6-month probiotics and calcium supplementation at 1–6 years of age on neurodevelopment in adolescence, along with the effects of other biomedical and socioenvironmental factors. We re-enrolled 238 adolescents 10-years after supplementation with low-lactose milk with either low calcium (LC; ∼50 mg/d; n = 53), regular calcium (RC; ∼440 mg/d; n = 70), RC with 5x10<sup>8</sup> CFU/d <em>Lactobacillus reuteri</em> DSM17938 (reuteri; n = 55), or RC with 5x10<sup>8</sup> CFU/d <em>L. casei</em> CRL431 (casei; n = 60). Compared to RC, the casei group scored 0.38 SD (effect size, 0.04–0.72) higher on the Raven’s Progressive Matrices; the reuteri group was 0.38 SD (0.01–0.75) lower on the Children’s Depression Inventory; and the LC and younger adolescents in the reuteri group were 0.36 (0.01–0.71) and 0.49 SD (0.02–0.95) lower in brain-derived neurotrophic factor. Diet quality, physical activity, and home environment contributed similar effect sizes. Probiotics supplementation in childhood have strain-specific long-term neurodevelopmental benefits and integration with socioenvironmental interventions are warranted.</p> |
| first_indexed | 2024-03-07T07:01:10Z |
| format | Journal article |
| id | oxford-uuid:27183edc-2fcb-4dac-a95d-d2d245ffc12e |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-07T07:01:10Z |
| publishDate | 2022 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:27183edc-2fcb-4dac-a95d-d2d245ffc12e2022-03-29T12:33:44ZLong-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27183edc-2fcb-4dac-a95d-d2d245ffc12eEnglishSymplectic ElementsElsevier2022Rianda, DSuradijono, SHRSetiawan, EASusanto, FMeilianawati, MPrafiantini, EKok, FJShankar, AHAgustina, R<p>We evaluated the impact of 6-month probiotics and calcium supplementation at 1–6 years of age on neurodevelopment in adolescence, along with the effects of other biomedical and socioenvironmental factors. We re-enrolled 238 adolescents 10-years after supplementation with low-lactose milk with either low calcium (LC; ∼50 mg/d; n = 53), regular calcium (RC; ∼440 mg/d; n = 70), RC with 5x10<sup>8</sup> CFU/d <em>Lactobacillus reuteri</em> DSM17938 (reuteri; n = 55), or RC with 5x10<sup>8</sup> CFU/d <em>L. casei</em> CRL431 (casei; n = 60). Compared to RC, the casei group scored 0.38 SD (effect size, 0.04–0.72) higher on the Raven’s Progressive Matrices; the reuteri group was 0.38 SD (0.01–0.75) lower on the Children’s Depression Inventory; and the LC and younger adolescents in the reuteri group were 0.36 (0.01–0.71) and 0.49 SD (0.02–0.95) lower in brain-derived neurotrophic factor. Diet quality, physical activity, and home environment contributed similar effect sizes. Probiotics supplementation in childhood have strain-specific long-term neurodevelopmental benefits and integration with socioenvironmental interventions are warranted.</p> |
| spellingShingle | Rianda, D Suradijono, SHR Setiawan, EA Susanto, F Meilianawati, M Prafiantini, E Kok, FJ Shankar, AH Agustina, R Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes |
| title | Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes |
| title_full | Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes |
| title_fullStr | Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes |
| title_full_unstemmed | Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes |
| title_short | Long-term benefits of probiotics and calcium supplementation during childhood, and other biomedical and socioenvironmental factors, on adolescent neurodevelopmental outcomes |
| title_sort | long term benefits of probiotics and calcium supplementation during childhood and other biomedical and socioenvironmental factors on adolescent neurodevelopmental outcomes |
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