Highly efficient depletion strategy for the two most abundant erythrocyte soluble proteins improves proteome coverage dramatically.

In-depth human erythrocyte proteome studies are severely hampered by the presence of hemoglobin and carbonic anhydrase-1, which account for more than 98% of the total erythrocyte soluble protein content. We developed a specific depletion approach that resulted in a drastic increase in the number of...

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Bibliographic Details
Main Authors: Ringrose, J, van Solinge, W, Mohammed, S, O'Flaherty, M, van Wijk, R, Heck, A, Slijper, M
Format: Journal article
Language:English
Published: 2008