The endothelium and the pathogenesis of atherosclerosis
The endothelium lining the vascular wall is a critical mediator of normal vascular homeostasis, playing important roles in blood pressure regulation, blood flow, inflammation and haemostasis. Abnormalities of endothelial function are a characteristic feature of vascular disease states and precede th...
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| Format: | Journal article |
| Language: | English |
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2006
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| _version_ | 1797059198037524480 |
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| author | Channon, K |
| author_facet | Channon, K |
| author_sort | Channon, K |
| collection | OXFORD |
| description | The endothelium lining the vascular wall is a critical mediator of normal vascular homeostasis, playing important roles in blood pressure regulation, blood flow, inflammation and haemostasis. Abnormalities of endothelial function are a characteristic feature of vascular disease states and precede the development of atherosclerotic plaques. Understanding the biology of the endothelium in health and disease provides insights into vascular disease initiation and progression. Similarly, advances in our understanding of the biology of the atherosclerotic plaque has clarified relationships between cellular and molecular events in the vessel wall and clinical events, and has paved the way for existing and novel treatments to reduce plaque progression and clinical risk. © 2006 Elsevier Ltd. All rights reserved. |
| first_indexed | 2024-03-06T20:00:48Z |
| format | Journal article |
| id | oxford-uuid:27387ece-8d15-45c8-bdf8-7c3b400147c0 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:00:48Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:27387ece-8d15-45c8-bdf8-7c3b400147c02022-03-26T12:05:40ZThe endothelium and the pathogenesis of atherosclerosisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27387ece-8d15-45c8-bdf8-7c3b400147c0EnglishSymplectic Elements at Oxford2006Channon, KThe endothelium lining the vascular wall is a critical mediator of normal vascular homeostasis, playing important roles in blood pressure regulation, blood flow, inflammation and haemostasis. Abnormalities of endothelial function are a characteristic feature of vascular disease states and precede the development of atherosclerotic plaques. Understanding the biology of the endothelium in health and disease provides insights into vascular disease initiation and progression. Similarly, advances in our understanding of the biology of the atherosclerotic plaque has clarified relationships between cellular and molecular events in the vessel wall and clinical events, and has paved the way for existing and novel treatments to reduce plaque progression and clinical risk. © 2006 Elsevier Ltd. All rights reserved. |
| spellingShingle | Channon, K The endothelium and the pathogenesis of atherosclerosis |
| title | The endothelium and the pathogenesis of atherosclerosis |
| title_full | The endothelium and the pathogenesis of atherosclerosis |
| title_fullStr | The endothelium and the pathogenesis of atherosclerosis |
| title_full_unstemmed | The endothelium and the pathogenesis of atherosclerosis |
| title_short | The endothelium and the pathogenesis of atherosclerosis |
| title_sort | endothelium and the pathogenesis of atherosclerosis |
| work_keys_str_mv | AT channonk theendotheliumandthepathogenesisofatherosclerosis AT channonk endotheliumandthepathogenesisofatherosclerosis |