K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of the human TREK-2 channel (up to 3.4 angstro...

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Bibliographic Details
Main Authors: Dong, Y, Pike, A, Mackenzie, A, McClenaghan, C, Aryal, P, Dong, L, Quigley, A, Grieben, M, Goubin, S, Mukhopadhyay, S, Ruda, G, Clausen, M, Cao, L, Brennan, P, Burgess-Brown, N, Sansom, M, Tucker, S, Carpenter, E
Format: Journal article
Language:English
Published: American Association for the Advancement of Science 2015

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