K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac

TREK-2 (KCNK10/K2P10), a two-pore domain potassium (K2P) channel, is gated by multiple stimuli such as stretch, fatty acids, and pH and by several drugs. However, the mechanisms that control channel gating are unclear. Here we present crystal structures of the human TREK-2 channel (up to 3.4 angstro...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Dong, Y, Pike, A, Mackenzie, A, McClenaghan, C, Aryal, P, Dong, L, Quigley, A, Grieben, M, Goubin, S, Mukhopadhyay, S, Ruda, G, Clausen, M, Cao, L, Brennan, P, Burgess-Brown, N, Sansom, M, Tucker, S, Carpenter, E
Format: Journal article
Język:English
Wydane: American Association for the Advancement of Science 2015

Podobne zapisy