Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination
The evidence associating red meat consumption and risk of multiple sclerosis is inconclusive. We tested associations between red meat consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), often presaging a diagnosis of multiple sclerosis. We used food freq...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal article |
| Language: | English |
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Frontiers Media
2019
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| _version_ | 1797059229339615232 |
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| author | Black, L Bowe, G Pereira, G Lucas, R Dear, K van Der Mei, I Sherriff, J Ausimmune Investigator Group |
| author2 | Dwyer, T |
| author_facet | Dwyer, T Black, L Bowe, G Pereira, G Lucas, R Dear, K van Der Mei, I Sherriff, J Ausimmune Investigator Group |
| author_sort | Black, L |
| collection | OXFORD |
| description | The evidence associating red meat consumption and risk of multiple sclerosis is inconclusive. We tested associations between red meat consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), often presaging a diagnosis of multiple sclerosis. We used food frequency questionnaire data from the 2003-2006 Ausimmune Study, an incident, matched, case-control study examining environmental risk factors for FCD. We calculated non-processed and processed red meat density (g/1,000 kcal/day). Conditional logistic regression models (with participants matched on age, sex, and study region) were used to estimate odds ratios (ORs), 95% confidence intervals (95% CI) and p-values for associations between non-processed (n = 689, 250 cases, 439 controls) and processed (n = 683, 248 cases, 435 controls) red meat density and risk of FCD. Models were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting. A one standard deviation increase in non-processed red meat density (22 g/1,000 kcal/day) was associated with a 19% reduced risk of FCD (AOR = 0.81; 95%CI 0.68, 0.97; p = 0.02). When stratified by sex, higher non-processed red meat density (per 22 g/1,000 kcal/day) was associated with a 26% reduced risk of FCD in females (n = 519; AOR = 0.74; 95%CI 0.60, 0.92; p = 0.01). There was no statistically significant association between non-processed red meat density and risk of FCD in males (n = 170). We found no statistically significant association between processed red meat density and risk of FCD. Further investigation is warranted to understand the important components of a diet that includes non-processed red meat for lower FCD risk. |
| first_indexed | 2024-03-06T20:01:12Z |
| format | Journal article |
| id | oxford-uuid:27592e5e-706d-4f52-a8ca-7788f0caa01a |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:01:12Z |
| publishDate | 2019 |
| publisher | Frontiers Media |
| record_format | dspace |
| spelling | oxford-uuid:27592e5e-706d-4f52-a8ca-7788f0caa01a2022-03-26T12:06:29ZHigher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System DemyelinationJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27592e5e-706d-4f52-a8ca-7788f0caa01aEnglishSymplectic Elements at OxfordFrontiers Media2019Black, LBowe, GPereira, GLucas, RDear, Kvan Der Mei, ISherriff, JAusimmune Investigator GroupDwyer, TThe evidence associating red meat consumption and risk of multiple sclerosis is inconclusive. We tested associations between red meat consumption and risk of a first clinical diagnosis of central nervous system demyelination (FCD), often presaging a diagnosis of multiple sclerosis. We used food frequency questionnaire data from the 2003-2006 Ausimmune Study, an incident, matched, case-control study examining environmental risk factors for FCD. We calculated non-processed and processed red meat density (g/1,000 kcal/day). Conditional logistic regression models (with participants matched on age, sex, and study region) were used to estimate odds ratios (ORs), 95% confidence intervals (95% CI) and p-values for associations between non-processed (n = 689, 250 cases, 439 controls) and processed (n = 683, 248 cases, 435 controls) red meat density and risk of FCD. Models were adjusted for history of infectious mononucleosis, serum 25-hydroxyvitamin D concentrations, smoking, race, education, body mass index and dietary misreporting. A one standard deviation increase in non-processed red meat density (22 g/1,000 kcal/day) was associated with a 19% reduced risk of FCD (AOR = 0.81; 95%CI 0.68, 0.97; p = 0.02). When stratified by sex, higher non-processed red meat density (per 22 g/1,000 kcal/day) was associated with a 26% reduced risk of FCD in females (n = 519; AOR = 0.74; 95%CI 0.60, 0.92; p = 0.01). There was no statistically significant association between non-processed red meat density and risk of FCD in males (n = 170). We found no statistically significant association between processed red meat density and risk of FCD. Further investigation is warranted to understand the important components of a diet that includes non-processed red meat for lower FCD risk. |
| spellingShingle | Black, L Bowe, G Pereira, G Lucas, R Dear, K van Der Mei, I Sherriff, J Ausimmune Investigator Group Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination |
| title | Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination |
| title_full | Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination |
| title_fullStr | Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination |
| title_full_unstemmed | Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination |
| title_short | Higher Non-processed Red Meat Consumption Is Associated With a Reduced Risk of Central Nervous System Demyelination |
| title_sort | higher non processed red meat consumption is associated with a reduced risk of central nervous system demyelination |
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