Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age
Objective: To assess and compare long-term pulmonary outcomes in former preterm-born, very low birth weight (VLBW) children with and without bronchopulmonary dysplasia (BPD) born in the surfactant era. Study design: Pulmonary function tests (ie, spirometry, body plethysmography, and gas transfer tes...
| Main Authors: | , , , |
|---|---|
| Format: | Journal article |
| Published: |
2013
|
| _version_ | 1797059264596934656 |
|---|---|
| author | vom Hove, M Prenzel, F Uhlig, H Robel-Tillig, E |
| author_facet | vom Hove, M Prenzel, F Uhlig, H Robel-Tillig, E |
| author_sort | vom Hove, M |
| collection | OXFORD |
| description | Objective: To assess and compare long-term pulmonary outcomes in former preterm-born, very low birth weight (VLBW) children with and without bronchopulmonary dysplasia (BPD) born in the surfactant era. Study design: Pulmonary function tests (ie, spirometry, body plethysmography, and gas transfer testing) were performed in children with a history of VLBW and BPD (n = 28) and compared with a matched preterm-born VLBW control group (n = 28). Medical history was evaluated by questionnaire. Results: At time of follow-up (mean age, 9.5 years), respiratory symptoms (36% vs 8%) and receipt of asthma medication (21% vs 0%) were significantly more frequent in the preterm-born children with previous BPD than in those with no history of BPD. The children with a history of BPD had significantly lower values for forced expiratory volume in 1 second (z-score -1.27 vs -0.4; P = .008), forced vital capacity (z-score -1.39 vs -0.71 z-score; P = .022), and forced expiratory flow rate at 50% of forced vital capacity (z-score -2.21 vs -1.04; P = .048) compared with the preterm control group. Conclusion: Preterm-born children with a history of BPD are significantly more likely to have lung function abnormalities, such as airway obstruction and respiratory symptoms, at school age compared with preterm-born children without BPD. © 2013 Mosby, Inc. All rights reserved. |
| first_indexed | 2024-03-06T20:01:43Z |
| format | Journal article |
| id | oxford-uuid:27877773-197d-492a-9c6c-b1815e8ad1e9 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:01:43Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | oxford-uuid:27877773-197d-492a-9c6c-b1815e8ad1e92022-03-26T12:07:31ZPulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School AgeJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27877773-197d-492a-9c6c-b1815e8ad1e9Symplectic Elements at Oxford2013vom Hove, MPrenzel, FUhlig, HRobel-Tillig, EObjective: To assess and compare long-term pulmonary outcomes in former preterm-born, very low birth weight (VLBW) children with and without bronchopulmonary dysplasia (BPD) born in the surfactant era. Study design: Pulmonary function tests (ie, spirometry, body plethysmography, and gas transfer testing) were performed in children with a history of VLBW and BPD (n = 28) and compared with a matched preterm-born VLBW control group (n = 28). Medical history was evaluated by questionnaire. Results: At time of follow-up (mean age, 9.5 years), respiratory symptoms (36% vs 8%) and receipt of asthma medication (21% vs 0%) were significantly more frequent in the preterm-born children with previous BPD than in those with no history of BPD. The children with a history of BPD had significantly lower values for forced expiratory volume in 1 second (z-score -1.27 vs -0.4; P = .008), forced vital capacity (z-score -1.39 vs -0.71 z-score; P = .022), and forced expiratory flow rate at 50% of forced vital capacity (z-score -2.21 vs -1.04; P = .048) compared with the preterm control group. Conclusion: Preterm-born children with a history of BPD are significantly more likely to have lung function abnormalities, such as airway obstruction and respiratory symptoms, at school age compared with preterm-born children without BPD. © 2013 Mosby, Inc. All rights reserved. |
| spellingShingle | vom Hove, M Prenzel, F Uhlig, H Robel-Tillig, E Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age |
| title | Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age |
| title_full | Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age |
| title_fullStr | Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age |
| title_full_unstemmed | Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age |
| title_short | Pulmonary Outcome in Former Preterm, Very Low Birth Weight Children with Bronchopulmonary Dysplasia: A Case-Control Follow-Up at School Age |
| title_sort | pulmonary outcome in former preterm very low birth weight children with bronchopulmonary dysplasia a case control follow up at school age |
| work_keys_str_mv | AT vomhovem pulmonaryoutcomeinformerpretermverylowbirthweightchildrenwithbronchopulmonarydysplasiaacasecontrolfollowupatschoolage AT prenzelf pulmonaryoutcomeinformerpretermverylowbirthweightchildrenwithbronchopulmonarydysplasiaacasecontrolfollowupatschoolage AT uhligh pulmonaryoutcomeinformerpretermverylowbirthweightchildrenwithbronchopulmonarydysplasiaacasecontrolfollowupatschoolage AT robeltillige pulmonaryoutcomeinformerpretermverylowbirthweightchildrenwithbronchopulmonarydysplasiaacasecontrolfollowupatschoolage |