Cancer disease: integrative modelling approaches
Cancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced that is capable of linking together such processes to produce a detailed model of vascular tumour growth. The model is for...
| Main Authors: | , , , |
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| Format: | Journal article |
| Published: |
2006
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| _version_ | 1797059270093570048 |
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| author | Byrne, H Owen, M Alarcon, T Maini, P |
| author_facet | Byrne, H Owen, M Alarcon, T Maini, P |
| author_sort | Byrne, H |
| collection | OXFORD |
| description | Cancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced that is capable of linking together such processes to produce a detailed model of vascular tumour growth. The model is formulated as a hybrid cellular automaton and contains submodels that describe subcellular, cellular and tissue level features. Model simulations will be presented to illustrate the effect that coupling between these different elements has on the tumour's evolution and its response to chemotherapy. |
| first_indexed | 2024-03-06T20:01:48Z |
| format | Journal article |
| id | oxford-uuid:278f04f1-9ed9-4d4e-bc83-1751e2ad0184 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:01:48Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:278f04f1-9ed9-4d4e-bc83-1751e2ad01842022-03-26T12:07:41ZCancer disease: integrative modelling approachesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:278f04f1-9ed9-4d4e-bc83-1751e2ad0184Mathematical Institute - ePrints2006Byrne, HOwen, MAlarcon, TMaini, PCancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced that is capable of linking together such processes to produce a detailed model of vascular tumour growth. The model is formulated as a hybrid cellular automaton and contains submodels that describe subcellular, cellular and tissue level features. Model simulations will be presented to illustrate the effect that coupling between these different elements has on the tumour's evolution and its response to chemotherapy. |
| spellingShingle | Byrne, H Owen, M Alarcon, T Maini, P Cancer disease: integrative modelling approaches |
| title | Cancer disease: integrative modelling approaches |
| title_full | Cancer disease: integrative modelling approaches |
| title_fullStr | Cancer disease: integrative modelling approaches |
| title_full_unstemmed | Cancer disease: integrative modelling approaches |
| title_short | Cancer disease: integrative modelling approaches |
| title_sort | cancer disease integrative modelling approaches |
| work_keys_str_mv | AT byrneh cancerdiseaseintegrativemodellingapproaches AT owenm cancerdiseaseintegrativemodellingapproaches AT alarcont cancerdiseaseintegrativemodellingapproaches AT mainip cancerdiseaseintegrativemodellingapproaches |