Genetic architecture of declarative memory: implications for complex illnesses
Why do memory abilities vary so greatly across individuals and cognitive domains? Although memory functions are highly heritable, what exactly is being genetically transmitted? Here we review evidence for the contribution of both common and partially independent inheritance of distinct aspects of me...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Language: | English |
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SAGE Publications
2012
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| Subjects: |
| _version_ | 1826264066161639424 |
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| author | Bearden, C Karlsgodt, K Bachman, P van Erp, T Winkler, A Glahn, D |
| author_facet | Bearden, C Karlsgodt, K Bachman, P van Erp, T Winkler, A Glahn, D |
| author_sort | Bearden, C |
| collection | OXFORD |
| description | Why do memory abilities vary so greatly across individuals and cognitive domains? Although memory functions are highly heritable, what exactly is being genetically transmitted? Here we review evidence for the contribution of both common and partially independent inheritance of distinct aspects of memory function. We begin by discussing the assessment of long-term memory and its underlying neural and molecular basis. We then consider evidence for both specialist and generalist genes underlying individual variability in memory, indicating that carving memory into distinct subcomponents may yield important information regarding its genetic architecture. And finally we review evidence from both complex and single-gene disorders, which provide insight into the molecular mechanisms underlying the genetic basis of human memory function. |
| first_indexed | 2024-03-06T20:01:50Z |
| format | Journal article |
| id | oxford-uuid:2790b708-bc0a-4889-b3d2-1e375be24c7f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:01:50Z |
| publishDate | 2012 |
| publisher | SAGE Publications |
| record_format | dspace |
| spelling | oxford-uuid:2790b708-bc0a-4889-b3d2-1e375be24c7f2022-03-26T12:07:42ZGenetic architecture of declarative memory: implications for complex illnessesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:2790b708-bc0a-4889-b3d2-1e375be24c7fCognitive NeuroscienceMemoryNeurogeneticsNeuropsychologyNeurologyGenetics (medical sciences)NeuroscienceEnglishSymplectic Elements at OxfordSAGE Publications2012Bearden, CKarlsgodt, KBachman, Pvan Erp, TWinkler, AGlahn, DWhy do memory abilities vary so greatly across individuals and cognitive domains? Although memory functions are highly heritable, what exactly is being genetically transmitted? Here we review evidence for the contribution of both common and partially independent inheritance of distinct aspects of memory function. We begin by discussing the assessment of long-term memory and its underlying neural and molecular basis. We then consider evidence for both specialist and generalist genes underlying individual variability in memory, indicating that carving memory into distinct subcomponents may yield important information regarding its genetic architecture. And finally we review evidence from both complex and single-gene disorders, which provide insight into the molecular mechanisms underlying the genetic basis of human memory function. |
| spellingShingle | Cognitive Neuroscience Memory Neurogenetics Neuropsychology Neurology Genetics (medical sciences) Neuroscience Bearden, C Karlsgodt, K Bachman, P van Erp, T Winkler, A Glahn, D Genetic architecture of declarative memory: implications for complex illnesses |
| title | Genetic architecture of declarative memory: implications for complex illnesses |
| title_full | Genetic architecture of declarative memory: implications for complex illnesses |
| title_fullStr | Genetic architecture of declarative memory: implications for complex illnesses |
| title_full_unstemmed | Genetic architecture of declarative memory: implications for complex illnesses |
| title_short | Genetic architecture of declarative memory: implications for complex illnesses |
| title_sort | genetic architecture of declarative memory implications for complex illnesses |
| topic | Cognitive Neuroscience Memory Neurogenetics Neuropsychology Neurology Genetics (medical sciences) Neuroscience |
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