Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted...
| Asıl Yazarlar: | , |
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| Materyal Türü: | Journal article |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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| _version_ | 1826264083384500224 |
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| author | Okbay, A De Neve, J |
| author_facet | Okbay, A De Neve, J |
| author_sort | Okbay, A |
| collection | OXFORD |
| description | Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association. |
| first_indexed | 2024-03-06T20:02:04Z |
| format | Journal article |
| id | oxford-uuid:27a693d5-b5a0-4f07-a7ff-784eb72f3d12 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T20:02:04Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | oxford-uuid:27a693d5-b5a0-4f07-a7ff-784eb72f3d122022-03-26T12:08:13ZGenetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analysesJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27a693d5-b5a0-4f07-a7ff-784eb72f3d12Symplectic Elements at OxfordNature Publishing Group2016Okbay, ADe Neve, JVery few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association. |
| spellingShingle | Okbay, A De Neve, J Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| title | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| title_full | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| title_fullStr | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| title_full_unstemmed | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| title_short | Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses |
| title_sort | genetic variants associated with subjective well being depressive symptoms and neuroticism identified through genome wide analyses |
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