DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

Ubiquitylation had been considered limited to protein lysine residues, but other substrates have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3' hydroxyl of the adenosine diphosphate (ADP)-ribosyl moiety that can be linked to a protein, thus generating a hybrid...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Zhu, K, Suskiewicz, MJ, Hloušek-Kasun, A, Meudal, H, Mikoč, A, Aucagne, V, Ahel, D, Ahel, I
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	American Association for the Advancement of Science 2022

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Serine ADP-Ribosylation Depends on HPF1
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The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
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Serine is a new target residue for endogenous ADP-ribosylation on histones
gan: Leidecker, O, et al.
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Deregulated DNA ADP-ribosylation impairs telomere replication
gan: Wondisford, AR, et al.
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Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens
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