DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

Ubiquitylation had been considered limited to protein lysine residues, but other substrates have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3' hydroxyl of the adenosine diphosphate (ADP)-ribosyl moiety that can be linked to a protein, thus generating a hybrid...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Zhu, K, Suskiewicz, MJ, Hloušek-Kasun, A, Meudal, H, Mikoč, A, Aucagne, V, Ahel, D, Ahel, I
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	American Association for the Advancement of Science 2022

समान संसाधन

ADP-ribosylation: new facets of an ancient modification
द्वारा: Palazzo, L, और अन्य
प्रकाशित: (2017)

Reversible ADP-ribosylation of RNA
द्वारा: Munnur, D, और अन्य
प्रकाशित: (2019)

Beyond protein modification: the rise of non-canonical ADP-ribosylation
द्वारा: Schuller, M, और अन्य
प्रकाशित: (2022)

Specificity of reversible ADP-ribosylation and regulation of cellular processes
द्वारा: Crawford, K, और अन्य
प्रकाशित: (2017)

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA
द्वारा: Hloušek-Kasun, A, और अन्य
प्रकाशित: (2022)

Reversible mono-ADP-ribosylation of DNA breaks.
द्वारा: Munnur, D, और अन्य
प्रकाशित: (2017)

MacroD1 is a promiscuous ADP-ribosyl hydrolase localized to mitochondria
द्वारा: Agnew, T, और अन्य
प्रकाशित: (2018)

Studying catabolism of protein ADP-Ribosylation
द्वारा: Palazzo, L, और अन्य
प्रकाशित: (2017)

(ADP-ribosyl)hydrolases: structure, function, and biology
द्वारा: Rack, JGM, और अन्य
प्रकाशित: (2020)

HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
द्वारा: Suskiewicz, MJ, और अन्य
प्रकाशित: (2020)

Monitoring poly(ADP-ribosyl)glycohydrolase activity with a continuous fluorescent substrate
द्वारा: Drown, B, और अन्य
प्रकाशित: (2018)

Reanalysis of phosphoproteomics data uncovers ADP-ribosylation sites.
द्वारा: Matic, I, और अन्य
प्रकाशित: (2012)

(ADP-ribosyl)hydrolases: Structural basis for differential substrate recognition and inhibition
द्वारा: Rack, J, और अन्य
प्रकाशित: (2018)

DarTG is a novel toxin-antitoxin system that catalyses the reversible ADP-ribosylation of DNA
द्वारा: Ariza, A, और अन्य
प्रकाशित: (2017)

Interplay of histone marks with serine ADP-ribosylation
द्वारा: Bartlett, E, और अन्य
प्रकाशित: (2018)

Unrestrained poly-ADP-ribosylation provides insights into chromatin regulation and human disease
द्वारा: Prokhorova, E, और अन्य
प्रकाशित: (2021)

Serine ADP-ribosylation reversal by the hydrolase ARH3
द्वारा: Fontana, P, और अन्य
प्रकाशित: (2017)

Viral macro domains reverse protein ADP-ribosylation.
द्वारा: Li, C, और अन्य
प्रकाशित: (2016)

Serine ADP-Ribosylation Depends on HPF1
द्वारा: Bonfiglio, J, और अन्य
प्रकाशित: (2017)

Molecular tools for the study of ADP-ribosylation: a unified and versatile method to synthesise native mono-ADP-ribosylated peptides
द्वारा: Voorneveld, J, और अन्य
प्रकाशित: (2021)

Serine is the major residue for ADP-ribosylation upon DNA damage
द्वारा: Palazzo, L, और अन्य
प्रकाशित: (2018)

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
द्वारा: Rack, JGM, और अन्य
प्रकाशित: (2021)

ENPP1 processes protein ADP-ribosylation in vitro.
द्वारा: Palazzo, L, और अन्य
प्रकाशित: (2016)

Discovery of reversing enzymes for RNA ADP-ribosylation reveals a possible defence module against toxic attack
द्वारा: Lu, Y, और अन्य
प्रकाशित: (2025)

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
द्वारा: Kar, P, और अन्य
प्रकाशित: (2024)

Deregulated DNA ADP-ribosylation impairs telomere replication
द्वारा: Wondisford, AR, और अन्य
प्रकाशित: (2024)

The role of ADP-ribosylation in regulating DNA interstrand crosslink repair
द्वारा: Gunn, A, और अन्य
प्रकाशित: (2016)

Serine is a new target residue for endogenous ADP-ribosylation on histones
द्वारा: Leidecker, O, और अन्य
प्रकाशित: (2016)

Poly(ADP-ribosyl)ation /
द्वारा: Burkle, Alexander
प्रकाशित: (2006)

Identification of a class of protein ADP-ribosylating sirtuins in microbial pathogens
द्वारा: Rack, J, और अन्य
प्रकाशित: (2015)

DNA ADP-ribosylation stalls replication and is reversed by RecF-mediated homologous recombination and nucleotide excision repair
द्वारा: Lawarée, E, और अन्य
प्रकाशित: (2020)

Synthetic α- and β-Ser-ADP-ribosylated peptides reveal α-Ser-ADPr as the native epimer
द्वारा: Voorneveld, J, और अन्य
प्रकाशित: (2018)

HPF1/C4orf27 is a PARP-1-interacting protein that regulates PARP-1 ADP-ribosylation activity
द्वारा: Gibbs-Seymour, I, और अन्य
प्रकाशित: (2016)

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
द्वारा: Beijer, D, और अन्य
प्रकाशित: (2021)

Progress and outlook in studying the substrate specificities of PARPs and related enzymes
द्वारा: Suskiewicz, MJ, और अन्य
प्रकाशित: (2020)

Structural and functional analysis of serine-ADP-ribosylation
द्वारा: Fontana, P
प्रकाशित: (2018)

ADP-ribosylation in in vitro systems synthesizing adenovirus DNA.
द्वारा: Goding, C, और अन्य
प्रकाशित: (1983)

Structural and bioinformatic analysis of ADP-ribosylation, transcription, and splicing
द्वारा: Henfrey, CA
प्रकाशित: (2023)

Investigating the role of serine-ADP-ribosylation in human cells
द्वारा: Prokhorova, E
प्रकाशित: (2022)

NR4A nuclear receptors target Poly-ADP-Ribosylated DNA-PKcs protein to promote DNA repair
द्वारा: Munnur, D, और अन्य
प्रकाशित: (2019)