DELTEX E3 ligases ubiquitylate ADP-ribosyl modification on protein substrates

Ubiquitylation had been considered limited to protein lysine residues, but other substrates have recently emerged. Here, we show that DELTEX E3 ligases specifically target the 3' hydroxyl of the adenosine diphosphate (ADP)-ribosyl moiety that can be linked to a protein, thus generating a hybrid...

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Váldodahkkit: Zhu, K, Suskiewicz, MJ, Hloušek-Kasun, A, Meudal, H, Mikoč, A, Aucagne, V, Ahel, D, Ahel, I
Materiálatiipa: Journal article
Giella:English
Almmustuhtton: American Association for the Advancement of Science 2022

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