Cavitational mechanisms in ultrasound-accelerated fibrinolysis
The role of both inertial and stable cavitation was investigated during in vitro ultrasound-accelerated fibrinolysis by recombinant tissue plasminogen activator (rt-PA) in the presence and absence of Optison™. A unique treatment configuration applied ultrasound, rt-PA and Optison™ to the interior of...
| Principais autores: | , , |
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| Formato: | Journal article |
| Idioma: | English |
| Publicado em: |
Elsevier
2007
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| _version_ | 1826264100724801536 |
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| author | Prokop, A Soltani, A Roy, R |
| author_facet | Prokop, A Soltani, A Roy, R |
| author_sort | Prokop, A |
| collection | OXFORD |
| description | The role of both inertial and stable cavitation was investigated during in vitro ultrasound-accelerated fibrinolysis by recombinant tissue plasminogen activator (rt-PA) in the presence and absence of Optison™. A unique treatment configuration applied ultrasound, rt-PA and Optison™ to the interior of a plasma clot. Lysis efficacy was measured as clot weight reduction. Cavitational mechanisms were investigated by monitoring subharmonic and broadband noise. In the absence of Optison™, 1.7 MHz pulsed ultrasound with 1.5 MPa peak-negative pressure applied for 30 min resulted in 45 ± 19% lysis enhancement relative to rt-PA alone. Cavitation was not detected, indicating a role of noncavitational effects of ultrasound. The addition of Optison™ increased lysis enhancement to 88 ± 25%. Inertial cavitation was present only at the start of the exposure, while low-amplitude subharmonic emissions persisted throughout. Additional protocols suggested a possible correlation between the increased lysis in the presence of Optison™ and the subharmonic emission, indicating a potentially important role of stable rather than inertial cavitation in microbubble-enhanced ultrasound-accelerated rt-PA-mediated thrombolysis. |
| first_indexed | 2024-03-06T20:02:21Z |
| format | Journal article |
| id | oxford-uuid:27bff91a-c7d2-4d2f-9ab8-16e213b3d14f |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:02:21Z |
| publishDate | 2007 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:27bff91a-c7d2-4d2f-9ab8-16e213b3d14f2022-03-26T12:08:41ZCavitational mechanisms in ultrasound-accelerated fibrinolysisJournal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27bff91a-c7d2-4d2f-9ab8-16e213b3d14fEnglishSymplectic Elements at OxfordElsevier2007Prokop, ASoltani, ARoy, RThe role of both inertial and stable cavitation was investigated during in vitro ultrasound-accelerated fibrinolysis by recombinant tissue plasminogen activator (rt-PA) in the presence and absence of Optison™. A unique treatment configuration applied ultrasound, rt-PA and Optison™ to the interior of a plasma clot. Lysis efficacy was measured as clot weight reduction. Cavitational mechanisms were investigated by monitoring subharmonic and broadband noise. In the absence of Optison™, 1.7 MHz pulsed ultrasound with 1.5 MPa peak-negative pressure applied for 30 min resulted in 45 ± 19% lysis enhancement relative to rt-PA alone. Cavitation was not detected, indicating a role of noncavitational effects of ultrasound. The addition of Optison™ increased lysis enhancement to 88 ± 25%. Inertial cavitation was present only at the start of the exposure, while low-amplitude subharmonic emissions persisted throughout. Additional protocols suggested a possible correlation between the increased lysis in the presence of Optison™ and the subharmonic emission, indicating a potentially important role of stable rather than inertial cavitation in microbubble-enhanced ultrasound-accelerated rt-PA-mediated thrombolysis. |
| spellingShingle | Prokop, A Soltani, A Roy, R Cavitational mechanisms in ultrasound-accelerated fibrinolysis |
| title | Cavitational mechanisms in ultrasound-accelerated fibrinolysis |
| title_full | Cavitational mechanisms in ultrasound-accelerated fibrinolysis |
| title_fullStr | Cavitational mechanisms in ultrasound-accelerated fibrinolysis |
| title_full_unstemmed | Cavitational mechanisms in ultrasound-accelerated fibrinolysis |
| title_short | Cavitational mechanisms in ultrasound-accelerated fibrinolysis |
| title_sort | cavitational mechanisms in ultrasound accelerated fibrinolysis |
| work_keys_str_mv | AT prokopa cavitationalmechanismsinultrasoundacceleratedfibrinolysis AT soltania cavitationalmechanismsinultrasoundacceleratedfibrinolysis AT royr cavitationalmechanismsinultrasoundacceleratedfibrinolysis |