Congenital Zika syndrome is associated with maternal protein malnutrition.
Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevan...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal article |
| Language: | English |
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American Association for the Advancement of Science
2020
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| _version_ | 1826264103499333632 |
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| author | Barbeito-Andrés, J Pezzuto, P Higa, LM Dias, AA Vasconcelos, JM Santos, TMP Ferreira, JCCG Ferreira, RO Dutra, FF Rossi, AD Barbosa, RV Amorim, CKN De Souza, MPC Chimelli, L Aguiar, RS Gonzalez, PN Lara, FA Castro, MC Molnár, Z Lopes, RT Bozza, MT Vianez, JLSG Barbeito, CG Cuervo, P Bellio, M Tanuri, A Garcez, PP |
| author_facet | Barbeito-Andrés, J Pezzuto, P Higa, LM Dias, AA Vasconcelos, JM Santos, TMP Ferreira, JCCG Ferreira, RO Dutra, FF Rossi, AD Barbosa, RV Amorim, CKN De Souza, MPC Chimelli, L Aguiar, RS Gonzalez, PN Lara, FA Castro, MC Molnár, Z Lopes, RT Bozza, MT Vianez, JLSG Barbeito, CG Cuervo, P Bellio, M Tanuri, A Garcez, PP |
| author_sort | Barbeito-Andrés, J |
| collection | OXFORD |
| description | Zika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS. |
| first_indexed | 2024-03-06T20:02:24Z |
| format | Journal article |
| id | oxford-uuid:27c2b642-753a-43cc-9c45-c5714ba84b46 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T20:02:24Z |
| publishDate | 2020 |
| publisher | American Association for the Advancement of Science |
| record_format | dspace |
| spelling | oxford-uuid:27c2b642-753a-43cc-9c45-c5714ba84b462022-03-26T12:08:52ZCongenital Zika syndrome is associated with maternal protein malnutrition.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:27c2b642-753a-43cc-9c45-c5714ba84b46EnglishSymplectic ElementsAmerican Association for the Advancement of Science2020Barbeito-Andrés, JPezzuto, PHiga, LMDias, AAVasconcelos, JMSantos, TMPFerreira, JCCGFerreira, RODutra, FFRossi, ADBarbosa, RVAmorim, CKNDe Souza, MPCChimelli, LAguiar, RSGonzalez, PNLara, FACastro, MCMolnár, ZLopes, RTBozza, MTVianez, JLSGBarbeito, CGCuervo, PBellio, MTanuri, AGarcez, PPZika virus (ZIKV) infection during pregnancy is associated with a spectrum of developmental impairments known as congenital Zika syndrome (CZS). The prevalence of this syndrome varies across ZIKV endemic regions, suggesting that its occurrence could depend on cofactors. Here, we evaluate the relevance of protein malnutrition for the emergence of CZS. Epidemiological data from the ZIKV outbreak in the Americas suggest a relationship between undernutrition and cases of microcephaly. To experimentally examine this relationship, we use immunocompetent pregnant mice, which were subjected to protein malnutrition and infected with a Brazilian ZIKV strain. We found that the combination of protein restriction and ZIKV infection leads to severe alterations of placental structure and embryonic body growth, with offspring displaying a reduction in neurogenesis and postnatal brain size. RNA-seq analysis reveals gene expression deregulation required for brain development in infected low-protein progeny. These results suggest that maternal protein malnutrition increases susceptibility to CZS. |
| spellingShingle | Barbeito-Andrés, J Pezzuto, P Higa, LM Dias, AA Vasconcelos, JM Santos, TMP Ferreira, JCCG Ferreira, RO Dutra, FF Rossi, AD Barbosa, RV Amorim, CKN De Souza, MPC Chimelli, L Aguiar, RS Gonzalez, PN Lara, FA Castro, MC Molnár, Z Lopes, RT Bozza, MT Vianez, JLSG Barbeito, CG Cuervo, P Bellio, M Tanuri, A Garcez, PP Congenital Zika syndrome is associated with maternal protein malnutrition. |
| title | Congenital Zika syndrome is associated with maternal protein malnutrition. |
| title_full | Congenital Zika syndrome is associated with maternal protein malnutrition. |
| title_fullStr | Congenital Zika syndrome is associated with maternal protein malnutrition. |
| title_full_unstemmed | Congenital Zika syndrome is associated with maternal protein malnutrition. |
| title_short | Congenital Zika syndrome is associated with maternal protein malnutrition. |
| title_sort | congenital zika syndrome is associated with maternal protein malnutrition |
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