The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.

The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways.

Ovarian cancers migrate and metastasize over the surface of the peritoneal cavity. Consequently, dysregulation of mechanisms that limit cell migration may be particularly important in the pathogenesis of the disease. ARHI is an imprinted tumor-suppressor gene that is downregulated in >60% of...

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Bibliographic Details
Main Authors: Badgwell, D, Lu, Z, Le, K, Gao, F, Yang, M, Suh, G, Bao, J, Das, P, Andreeff, M, Chen, W, Yu, Y, Ahmed, A, S-L Liao, W, Bast, R
Format: Journal article
Language:English
Published: 2012

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