Self-liganded Suzuki-Miyaura coupling for site-selective protein PEGylation.
Building with PEGs: PEG-boronic acids, in the presence of simple Pd sources, are capable of acting as direct and effective Suzuki reagents in 70-98 % yield. When combined with non-natural amino acids, they allow efficient and direct, site-selective PEGylation of proteins at predetermined positions u...
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| Hlavní autoři: |
Dumas, A,
Spicer, C,
Gao, Z,
Takehana, T,
Lin, Y,
Yasukohchi, T,
Davis, B |
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| Médium: | Journal article
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| Jazyk: | English |
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| Vydáno: |
2013
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